Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ALX03815.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (541 aa)    
Predicted Functional Partners:
ALX05769.1
Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.
 
0.937
ALX05219.1
ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 
0.924
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.844
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
 
  
   0.799
recA
Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.764
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.742
ALX03446.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.708
ALX04055.1
ABC transporter ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   0.648
ALX03897.1
ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.643
ALX05175.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.631
Your Current Organism:
Aeromicrobium erythreum
NCBI taxonomy Id: 2041
Other names: A. erythreum, ATCC 51598, DSM 8599, JCM 8359, LMG 16472, LMG:16472, NBRC 15406, NRRL B-3381
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.