Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ALX04449.1Methionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)    
Predicted Functional Partners:
ALX05121.1
5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.928
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 0.869
mnmA
Thiouridylase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
 
   
 0.858
ALX04827.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
  
 0.842
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.805
ALX04447.1
Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.795
ALX04561.1
GCN5 family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.715
ALX05223.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.678
ALX05143.1
ErfK/YbiS/YcfS/YnhG family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.662
ALX03244.1
O-acetyl-L-homoserine sulfhydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.641
Your Current Organism:
Aeromicrobium erythreum
NCBI taxonomy Id: 2041
Other names: A. erythreum, ATCC 51598, DSM 8599, JCM 8359, LMG 16472, LMG:16472, NBRC 15406, NRRL B-3381
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