C824_00746 protein (Schaedlerella arabinosiphila)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

C824_00746

Uncharacterized protein. (75 aa)

Predicted Functional Partners:

C824_00747

0.773

C824_00745

0.568

C824_00744

0.504

C824_00741

0.477

C824_00742

0.477

C824_00743

0.477

C824_00738

0.460

C824_00739

0.460

C824_00740

0.460

C824_00734

0.434

Your Current Organism:

Schaedlerella arabinosiphila

NCBI taxonomy Id: 2044587
Other names: Clostridiaceae bacterium DSM 106076, Clostridiales bacterium TLL-A1, Clostridium sp. ASF502, DSM 106076, KCTC 15657, S. arabinosiphila, Schaedlerella arabinosiphila Soh et al. 2019, personal::TLL-A1T, strain TLL-A1T

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... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
C824_00734	C824_00738	Uncharacterized protein.	Uncharacterized protein.	0.723
C824_00734	C824_00739	Uncharacterized protein.	Uncharacterized protein.	0.723
C824_00734	C824_00740	Uncharacterized protein.	Uncharacterized protein.	0.723
C824_00734	C824_00741	Uncharacterized protein.	Methyltransferase; Belongs to the N(4)/N(6)-methyltransferase family.	0.693
C824_00734	C824_00742	Uncharacterized protein.	Uncharacterized protein.	0.693
C824_00734	C824_00743	Uncharacterized protein.	Cytosine-specific methyltransferase.	0.693
C824_00734	C824_00744	Uncharacterized protein.	DarA_C domain-containing protein.	0.653
C824_00734	C824_00745	Uncharacterized protein.	Uncharacterized protein.	0.576
C824_00734	C824_00746	Uncharacterized protein.	Uncharacterized protein.	0.434
C824_00734	C824_00747	Uncharacterized protein.	Uncharacterized protein.	0.434
C824_00738	C824_00734	Uncharacterized protein.	Uncharacterized protein.	0.723
C824_00738	C824_00739	Uncharacterized protein.	Uncharacterized protein.	0.773
C824_00738	C824_00740	Uncharacterized protein.	Uncharacterized protein.	0.773
C824_00738	C824_00741	Uncharacterized protein.	Methyltransferase; Belongs to the N(4)/N(6)-methyltransferase family.	0.741
C824_00738	C824_00742	Uncharacterized protein.	Uncharacterized protein.	0.741
C824_00738	C824_00743	Uncharacterized protein.	Cytosine-specific methyltransferase.	0.741
C824_00738	C824_00744	Uncharacterized protein.	DarA_C domain-containing protein.	0.698
C824_00738	C824_00745	Uncharacterized protein.	Uncharacterized protein.	0.614
C824_00738	C824_00746	Uncharacterized protein.	Uncharacterized protein.	0.460
C824_00738	C824_00747	Uncharacterized protein.	Uncharacterized protein.	0.460

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.944

expected number of edges:

12

PPI enrichment p-value:

8.06e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000651

Positive regulation of sodium ion transmembrane transporter activity

2 of 3

2.84

0.87

0.0274

GO:1903288

Positive regulation of potassium ion import across plasma membrane

2 of 2

3.01

0.87

0.0274

GO:0010766

Negative regulation of sodium ion transport

2 of 4

2.71

0.86

0.0274

GO:0050794

Regulation of cellular process

10 of 3282

0.5

0.33

0.0274

GO:0065007

Biological regulation

11 of 4007

0.45

0.31

0.0274

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019869

Chloride channel inhibitor activity

2 of 2

3.01

1.31

0.0044

GO:0003712

Transcription coregulator activity

5 of 175

1.47

1.3

0.00070

GO:0019870

Potassium channel inhibitor activity

2 of 3

2.84

1.3

0.0044

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016592

Mediator complex

5 of 30

2.24

3.45

9.69e-08

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6417

Mediator complex

6 of 29

2.33

4.56

4.55e-10

CL:6419

Mediator complex

5 of 24

2.33

4.06

6.71e-09

CL:6429

Activator

3 of 5

2.79

2.88

4.94e-06

CL:15528

Sulfuric ester hydrolase activity, and HS-GAG degradation

2 of 19

2.04

0.91

0.0191

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-212436

Generic Transcription Pathway

6 of 695

0.95

0.56

0.0258

MAP-73857

RNA Polymerase II Transcription

6 of 805

0.89

0.52

0.0297

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0010

Activator

5 of 22

2.37

4.11

6.34e-09

KW-0805

Transcription regulation

5 of 119

1.64

2.05

8.47e-06

KW-0539

Nucleus

5 of 475

1.04

0.79

0.0033

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08638

Mediator complex subunit MED14

2 of 2

3.01

1.26

0.0054

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013947

Mediator complex, subunit Med14

2 of 2

3.01

0.98

0.0170

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