C824_05003 protein (Schaedlerella arabinosiphila)

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

C824_05003

HATPase_c_5 domain-containing protein. (447 aa)

Predicted Functional Partners:

C824_05002

0.904

C824_00392

0.737

C824_03967

0.717

C824_02836

0.682

C824_04124

0.664

C824_04381

0.663

C824_05397

0.640

C824_02996

0.639

C824_01990

0.629

C824_00599

0.617

Your Current Organism:

Schaedlerella arabinosiphila

NCBI taxonomy Id: 2044587
Other names: Clostridiaceae bacterium DSM 106076, Clostridiales bacterium TLL-A1, Clostridium sp. ASF502, DSM 106076, KCTC 15657, S. arabinosiphila, Schaedlerella arabinosiphila Soh et al. 2019, personal::TLL-A1T, strain TLL-A1T

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
C824_00392	C824_05003	Uncharacterized protein.	HATPase_c_5 domain-containing protein.	0.737
C824_00599	C824_05003	DNA-binding response regulator.	HATPase_c_5 domain-containing protein.	0.617
C824_01990	C824_02996	Response regulatory domain-containing protein.	DNA-binding response regulator.	0.769
C824_01990	C824_05003	Response regulatory domain-containing protein.	HATPase_c_5 domain-containing protein.	0.629
C824_02836	C824_04381	Uncharacterized protein.	Uncharacterized protein.	0.996
C824_02836	C824_05003	Uncharacterized protein.	HATPase_c_5 domain-containing protein.	0.682
C824_02996	C824_01990	DNA-binding response regulator.	Response regulatory domain-containing protein.	0.769
C824_02996	C824_05003	DNA-binding response regulator.	HATPase_c_5 domain-containing protein.	0.639
C824_03967	C824_05003	Uncharacterized protein.	HATPase_c_5 domain-containing protein.	0.717
C824_04124	C824_05003	Response regulatory domain-containing protein.	HATPase_c_5 domain-containing protein.	0.664
C824_04381	C824_02836	Uncharacterized protein.	Uncharacterized protein.	0.996
C824_04381	C824_05003	Uncharacterized protein.	HATPase_c_5 domain-containing protein.	0.663
C824_05002	C824_05003	Uncharacterized protein.	HATPase_c_5 domain-containing protein.	0.904
C824_05003	C824_00392	HATPase_c_5 domain-containing protein.	Uncharacterized protein.	0.737
C824_05003	C824_00599	HATPase_c_5 domain-containing protein.	DNA-binding response regulator.	0.617
C824_05003	C824_01990	HATPase_c_5 domain-containing protein.	Response regulatory domain-containing protein.	0.629
C824_05003	C824_02836	HATPase_c_5 domain-containing protein.	Uncharacterized protein.	0.682
C824_05003	C824_02996	HATPase_c_5 domain-containing protein.	DNA-binding response regulator.	0.639
C824_05003	C824_03967	HATPase_c_5 domain-containing protein.	Uncharacterized protein.	0.717
C824_05003	C824_04124	HATPase_c_5 domain-containing protein.	Response regulatory domain-containing protein.	0.664

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.893

expected number of edges:

19

PPI enrichment p-value:

1.75e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019427

acetyl-CoA biosynthetic process from acetate

3 of 4

2.3

1.63

0.00085

GO:0032787

Monocarboxylic acid metabolic process

7 of 126

1.17

0.00012

GO:0006631

Fatty acid metabolic process

4 of 42

1.4

1.08

0.0025

GO:0015740

C4-dicarboxylate transport

2 of 10

1.72

0.72

0.0396

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016878

Acid-thiol ligase activity

5 of 20

1.82

2.24

9.43e-06

GO:0016208

AMP binding

3 of 4

2.3

1.84

0.00032

GO:0003987

acetate-CoA ligase activity

3 of 4

2.3

1.84

0.00032

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4795

Mixed, incl. beta-Alanine metabolism, and TRAP transporter, small membrane protein DctQ

5 of 5

2.42

3.8

3.61e-08

CL:4792

Mixed, incl. TRAP transporter, small membrane protein DctQ, and TRAP transporter solute receptor DctP

6 of 17

1.97

3.29

3.61e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00640

Propanoate metabolism

4 of 30

1.55

1.39

0.00058

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005759

Mitochondrial matrix

4 of 26

1.61

1.38

0.00084

GOCC:0031317

Tripartite ATP-independent periplasmic transporter complex

2 of 9

1.77

0.76

0.0343

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13193

AMP-binding enzyme C-terminal domain

5 of 14

1.97

2.71

1.44e-06

PF00501

AMP-binding enzyme

5 of 16

1.92

2.65

1.44e-06

PF16177

Acetyl-coenzyme A synthetase N-terminus

2 of 2

2.42

1.04

0.0123

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR025110

AMP-binding enzyme, C-terminal domain

5 of 14

1.97

2.54

3.88e-06

IPR020845

AMP-binding, conserved site

5 of 15

1.94

2.51

3.88e-06

IPR000873

AMP-dependent synthetase/ligase domain

5 of 15

1.94

2.51

3.88e-06

IPR045851

AMP-binding enzyme, C-terminal domain superfamily

5 of 16

1.92

2.49

3.88e-06

IPR042099

ANL, N-terminal domain

5 of 16

1.92

2.49

3.88e-06

(more ...)

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