ssuD_4 protein (Pimelobacter simplex) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ssuD_4

Nitrilotriacetate monooxygenase component A. (426 aa)

Predicted Functional Partners:

AIY19229.1

0.815

ssuD_3

0.780

AIY18741.1

0.771

AJR18675.1

0.768

AIY19304.1

0.768

lipL

0.767

AJR18608.1

0.765

AJR18782.1

0.762

AIY18740.2

0.746

AIY18742.1

0.743

Your Current Organism:

Pimelobacter simplex

NCBI taxonomy Id: 2045
Other names: ATCC 6946, Arthrobacter simplex, CCUG 23611, CIP 82.106, Corynebacterium simplex, DSM 20130, HAMBI 90, IFO 12069, KCTC 9106, LMG 16261, LMG:16261, NBRC 12069, NCIB 8929, NCIB:8929, Nocardioides simplex, P. simplex

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIY18740.2	AIY18741.1	KR76_21715	KR76_21720	FMN reductase.	Alkanesulfonate monooxygenase.	0.992
AIY18740.2	AIY18742.1	KR76_21715	KR76_21725	FMN reductase.	Acyl-CoA dehydrogenase.	0.797
AIY18740.2	AIY19304.1	KR76_21715	KR76_25605	FMN reductase.	FMN reductase.	0.902
AIY18740.2	AJR18608.1	KR76_21715	KR76_19245	FMN reductase.	Alkanesulfonate monooxygenase.	0.714
AIY18740.2	AJR18675.1	KR76_21715	KR76_21735	FMN reductase.	Acyl-CoA dehydrogenase.	0.608
AIY18740.2	ssuD_3	KR76_21715	KR76_19250	FMN reductase.	Alkanesulfonate monooxygenase.	0.733
AIY18740.2	ssuD_4	KR76_21715	KR76_25050	FMN reductase.	Nitrilotriacetate monooxygenase component A.	0.746
AIY18741.1	AIY18740.2	KR76_21720	KR76_21715	Alkanesulfonate monooxygenase.	FMN reductase.	0.992
AIY18741.1	AIY18742.1	KR76_21720	KR76_21725	Alkanesulfonate monooxygenase.	Acyl-CoA dehydrogenase.	0.933
AIY18741.1	AIY19304.1	KR76_21720	KR76_25605	Alkanesulfonate monooxygenase.	FMN reductase.	0.972
AIY18741.1	AJR18675.1	KR76_21720	KR76_21735	Alkanesulfonate monooxygenase.	Acyl-CoA dehydrogenase.	0.835
AIY18741.1	ssuD_4	KR76_21720	KR76_25050	Alkanesulfonate monooxygenase.	Nitrilotriacetate monooxygenase component A.	0.771
AIY18742.1	AIY18740.2	KR76_21725	KR76_21715	Acyl-CoA dehydrogenase.	FMN reductase.	0.797
AIY18742.1	AIY18741.1	KR76_21725	KR76_21720	Acyl-CoA dehydrogenase.	Alkanesulfonate monooxygenase.	0.933
AIY18742.1	AJR18608.1	KR76_21725	KR76_19245	Acyl-CoA dehydrogenase.	Alkanesulfonate monooxygenase.	0.718
AIY18742.1	AJR18675.1	KR76_21725	KR76_21735	Acyl-CoA dehydrogenase.	Acyl-CoA dehydrogenase.	0.625
AIY18742.1	ssuD_3	KR76_21725	KR76_19250	Acyl-CoA dehydrogenase.	Alkanesulfonate monooxygenase.	0.749
AIY18742.1	ssuD_4	KR76_21725	KR76_25050	Acyl-CoA dehydrogenase.	Nitrilotriacetate monooxygenase component A.	0.743
AIY19229.1	AJR18782.1	KR76_25045	KR76_25055	Nitrilotriacetate monooxygenase component B.	Hypothetical protein.	0.771
AIY19229.1	lipL	KR76_25045	KR76_25060	Nitrilotriacetate monooxygenase component B.	Esterase A.	0.768

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.532

expected number of edges:

11

PPI enrichment p-value:

1.07e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

6 of 176

1.98

3.6

1.46e-08

GO:0044255

Cellular lipid metabolic process

8 of 494

1.66

3.13

8.30e-10

GO:0006635

Fatty acid beta-oxidation

3 of 42

2.3

2.08

0.00019

GO:0009437

Carnitine metabolic process

2 of 9

2.8

1.64

0.0016

GO:0008610

Lipid biosynthetic process

4 of 289

1.59

1.48

0.00059

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004095

Carnitine O-palmitoyltransferase activity

3 of 3

3.45

3.52

1.10e-06

GO:0004467

Long-chain fatty acid-CoA ligase activity

3 of 6

3.15

3.5

1.10e-06

GO:0008374

O-acyltransferase activity

4 of 40

2.45

3.3

1.10e-06

GO:0016740

Transferase activity

5 of 1946

0.86

0.51

0.0306

GO:0003824

Catalytic activity

8 of 5382

0.62

0.46

0.0038

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18877

Long-chain fatty acid-CoA ligase activity, and O-palmitoyltransferase activity

5 of 6

3.37

7.01

1.05e-12

CL:18825

Glycerolipid metabolism, and Long-chain fatty acid-CoA ligase activity

6 of 32

2.72

6.59

1.05e-12

CL:18823

Mixed, incl. Glycerolipid metabolism, and Sphingolipid metabolism

7 of 82

2.38

6.14

6.15e-13

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pdam00071

Fatty acid degradation

6 of 27

2.8

7.46

3.12e-14

pdam01212

Fatty acid metabolism

6 of 33

2.71

7.26

4.60e-14

pdam00061

Fatty acid biosynthesis

3 of 9

2.97

3.81

2.83e-07

pdam04146

Peroxisome

2 of 61

1.97

1.24

0.0054

pdam01100

Metabolic pathways

4 of 896

1.1

0.82

0.0054

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8978868

Fatty acid metabolism

6 of 184

1.96

3.68

6.77e-09

MAP-75876

Synthesis of very long-chain fatty acyl-CoAs

3 of 16

2.72

2.95

7.56e-06

MAP-556833

Metabolism of lipids

8 of 633

1.55

2.77

1.41e-09

MAP-75105

Fatty acyl-CoA biosynthesis

3 of 32

2.42

2.47

4.07e-05

MAP-200425

Carnitine metabolism

3 of 45

2.27

2.24

8.95e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005811

Lipid droplet

2 of 34

2.22

0.83

0.0363

GOCC:0005737

Cytoplasm

8 of 4164

0.73

0.54

0.0047

GOCC:0043229

Intracellular organelle

8 of 5925

0.58

0.36

0.0363

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00755

Choline/Carnitine o-acyltransferase

3 of 5

3.23

3.28

2.65e-06

PF00501

AMP-binding enzyme

3 of 21

2.61

2.48

4.78e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042231

Choline/Carnitine o-acyltransferase, domain 2

3 of 5

3.23

3.02

7.42e-06

IPR039551

Choline/carnitine acyltransferase domain

3 of 5

3.23

3.02

7.42e-06

IPR000542

Acyltransferase ChoActase/COT/CPT

3 of 5

3.23

3.02

7.42e-06

IPR023213

Chloramphenicol acetyltransferase-like domain superfamily

3 of 15

2.75

2.64

2.70e-05

IPR020845

AMP-binding, conserved site

3 of 17

2.7

2.61

3.02e-05

(more ...)

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