| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HEAR1756 | ispA | HEAR1756 | HEAR0278 | Putative phytoene synthase CrtB-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Geranyltranstransferase (Farnesyl-diphosphate synthase) (FPP synthase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FPP/GGPP synthase family. | 0.923 |
| HEAR1756 | ispB | HEAR1756 | HEAR2788 | Putative phytoene synthase CrtB-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Octaprenyl-diphosphate synthase (Octaprenyl pyrophosphate synthetase) (OPP synthetase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FPP/GGPP synthase family. | 0.902 |
| HEAR1756 | uppS | HEAR1756 | HEAR1339 | Putative phytoene synthase CrtB-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Isoprenyl transferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.829 |
| aroBK | dxs | HEAR3120 | HEAR0279 | Bifunctional protein [Includes: 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.443 |
| aroBK | ispA | HEAR3120 | HEAR0278 | Bifunctional protein [Includes: 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Geranyltranstransferase (Farnesyl-diphosphate synthase) (FPP synthase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FPP/GGPP synthase family. | 0.588 |
| aroBK | ispB | HEAR3120 | HEAR2788 | Bifunctional protein [Includes: 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Octaprenyl-diphosphate synthase (Octaprenyl pyrophosphate synthetase) (OPP synthetase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FPP/GGPP synthase family. | 0.534 |
| aroBK | ispH | HEAR3120 | HEAR2466 | Bifunctional protein [Includes: 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.436 |
| dxs | aroBK | HEAR0279 | HEAR3120 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Bifunctional protein [Includes: 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.443 |
| dxs | folE2 | HEAR0279 | HEAR0280 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.656 |
| dxs | ispA | HEAR0279 | HEAR0278 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Geranyltranstransferase (Farnesyl-diphosphate synthase) (FPP synthase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FPP/GGPP synthase family. | 0.867 |
| dxs | ispH | HEAR0279 | HEAR2466 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.834 |
| dxs | thiL | HEAR0279 | HEAR0642 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Thiamin-monophosphate kinase (Thiamine-phosphate kinase); Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.423 |
| dxs | xseB | HEAR0279 | HEAR0277 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Exodeoxyribonuclease VII small subunit (Exonuclease VII small subunit) (XseB); Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. | 0.795 |
| folE2 | dxs | HEAR0280 | HEAR0279 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.656 |
| folE2 | ispA | HEAR0280 | HEAR0278 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | Geranyltranstransferase (Farnesyl-diphosphate synthase) (FPP synthase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FPP/GGPP synthase family. | 0.596 |
| folE2 | xseB | HEAR0280 | HEAR0277 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | Exodeoxyribonuclease VII small subunit (Exonuclease VII small subunit) (XseB); Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. | 0.596 |
| ispA | HEAR1756 | HEAR0278 | HEAR1756 | Geranyltranstransferase (Farnesyl-diphosphate synthase) (FPP synthase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FPP/GGPP synthase family. | Putative phytoene synthase CrtB-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.923 |
| ispA | aroBK | HEAR0278 | HEAR3120 | Geranyltranstransferase (Farnesyl-diphosphate synthase) (FPP synthase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FPP/GGPP synthase family. | Bifunctional protein [Includes: 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.588 |
| ispA | dxs | HEAR0278 | HEAR0279 | Geranyltranstransferase (Farnesyl-diphosphate synthase) (FPP synthase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FPP/GGPP synthase family. | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.867 |
| ispA | folE2 | HEAR0278 | HEAR0280 | Geranyltranstransferase (Farnesyl-diphosphate synthase) (FPP synthase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FPP/GGPP synthase family. | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.596 |