node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HEAR0627 | HEAR2755 | HEAR0627 | HEAR2755 | Putative NUDIX hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative exoribonuclease II; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.710 |
HEAR0627 | cobD | HEAR0627 | HEAR0628 | Putative NUDIX hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative cobalamin biosynthesis protein CobD-like; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.547 |
HEAR0627 | nnrD | HEAR0627 | HEAR1745 | Putative NUDIX hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein, putative carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate deh [...] | 0.923 |
HEAR0627 | rimM | HEAR0627 | HEAR0624 | Putative NUDIX hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 16S rRNA processing protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. | 0.425 |
HEAR0627 | rnr | HEAR0627 | HEAR1277 | Putative NUDIX hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | RNase R, 3'-5' exoribonuclease; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.710 |
HEAR0627 | rph | HEAR0627 | HEAR2126 | Putative NUDIX hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Ribonuclease PH (RNase PH) (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.642 |
HEAR0627 | rplS | HEAR0627 | HEAR0626 | Putative NUDIX hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 50S ribosomal subunit protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.533 |
HEAR0627 | trmD | HEAR0627 | HEAR0625 | Putative NUDIX hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | tRNA (guanine-N(1)-)-methyltransferase) (M1G-methyltransferase) (tRNA [GM37] methyltransferase); Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. | 0.401 |
HEAR2755 | HEAR0627 | HEAR2755 | HEAR0627 | Putative exoribonuclease II; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative NUDIX hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.710 |
HEAR2755 | rph | HEAR2755 | HEAR2126 | Putative exoribonuclease II; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Ribonuclease PH (RNase PH) (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.936 |
cobD | HEAR0627 | HEAR0628 | HEAR0627 | Putative cobalamin biosynthesis protein CobD-like; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Putative NUDIX hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.547 |
nnrD | HEAR0627 | HEAR1745 | HEAR0627 | Conserved hypothetical protein, putative carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate deh [...] | Putative NUDIX hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.923 |
rimM | HEAR0627 | HEAR0624 | HEAR0627 | 16S rRNA processing protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. | Putative NUDIX hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.425 |
rimM | rplS | HEAR0624 | HEAR0626 | 16S rRNA processing protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. | 50S ribosomal subunit protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.963 |
rimM | trmD | HEAR0624 | HEAR0625 | 16S rRNA processing protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. | tRNA (guanine-N(1)-)-methyltransferase) (M1G-methyltransferase) (tRNA [GM37] methyltransferase); Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. | 0.982 |
rnr | HEAR0627 | HEAR1277 | HEAR0627 | RNase R, 3'-5' exoribonuclease; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | Putative NUDIX hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.710 |
rnr | rph | HEAR1277 | HEAR2126 | RNase R, 3'-5' exoribonuclease; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | Ribonuclease PH (RNase PH) (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.951 |
rph | HEAR0627 | HEAR2126 | HEAR0627 | Ribonuclease PH (RNase PH) (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | Putative NUDIX hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.642 |
rph | HEAR2755 | HEAR2126 | HEAR2755 | Ribonuclease PH (RNase PH) (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | Putative exoribonuclease II; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.936 |
rph | rnr | HEAR2126 | HEAR1277 | Ribonuclease PH (RNase PH) (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | RNase R, 3'-5' exoribonuclease; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.951 |