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ileS protein (Herminiimonas arsenicoxydans) - STRING interaction network
"ileS" - Isoleucine--tRNA ligase in Herminiimonas arsenicoxydans
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ileSIsoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as ’pretransfer’ editing and involves the hydrolysis of activated Val-AMP. The other activity is designated ’posttransfer’ editing and involves deacylation of mischarged Val-tRNA(Ile); Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily (959 aa)    
Predicted Functional Partners:
pheT
Phenylalanine--tRNA ligase beta subunit; Evidence 2a - Function of homologous gene experimentally demonstrated in an other organism; Product type e - enzyme; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily (809 aa)
   
 
  0.956
ribF
Riboflavin biosynthesis protein; Evidence 2a - Function of homologous gene experimentally demonstrated in an other organism; Product type e - enzyme; Belongs to the ribF family (325 aa)
 
   
  0.945
lysS
Lysine--tRNA ligase; Evidence 2a - Function of homologous gene experimentally demonstrated in an other organism; Product type e - enzyme; Belongs to the class-II aminoacyl-tRNA synthetase family (511 aa)
   
 
  0.928
leuS
Leucine--tRNA ligase; Evidence 2a - Function of homologous gene experimentally demonstrated in an other organism; Product type e - enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family (881 aa)
 
 
0.926
proS
Proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction- proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as ’pretransfer’ editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated ’posttransfer’ editing and involves deacy [...] (577 aa)
   
 
  0.925
alaS
Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (869 aa)
 
 
  0.921
lspA2
Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family (166 aa)
 
   
  0.907
cysS
Cysteine--tRNA ligase; Evidence 2a - Function of homologous gene experimentally demonstrated in an other organism; Product type e - enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family (462 aa)
 
   
  0.900
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (1336 aa)
   
   
  0.899
valS
Valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily (969 aa)
 
 
0.884
Your Current Organism:
Herminiimonas arsenicoxydans
NCBI taxonomy Id: 204773
Other names: CCM 7303, DSM 17148, H. arsenicoxydans, Herminiimonas arsenicoxydans, Herminiimonas arsenicoxydans Muller et al. 2006, LMG 22961, strain ULPAs1
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