| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HEAR3000 | HEAR3001 | HEAR3000 | HEAR3001 | D-amino-acid transaminase; Function of strongly homologous gene; enzyme. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | 0.882 |
| HEAR3000 | lipA | HEAR3000 | HEAR3003 | D-amino-acid transaminase; Function of strongly homologous gene; enzyme. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.582 |
| HEAR3000 | lipB | HEAR3000 | HEAR3002 | D-amino-acid transaminase; Function of strongly homologous gene; enzyme. | Lipoyl-[acyl-carrier-protein]-protein-N- lipoyltransferase (Lipoate-protein ligase B); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.714 |
| HEAR3001 | HEAR3000 | HEAR3001 | HEAR3000 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | D-amino-acid transaminase; Function of strongly homologous gene; enzyme. | 0.882 |
| HEAR3001 | lipA | HEAR3001 | HEAR3003 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.671 |
| HEAR3001 | lipB | HEAR3001 | HEAR3002 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | Lipoyl-[acyl-carrier-protein]-protein-N- lipoyltransferase (Lipoate-protein ligase B); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.890 |
| HEAR3004 | lipA | HEAR3004 | HEAR3003 | Metabolite transport protein; Function of strongly homologous gene; transporter. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.639 |
| lipA | HEAR3000 | HEAR3003 | HEAR3000 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | D-amino-acid transaminase; Function of strongly homologous gene; enzyme. | 0.582 |
| lipA | HEAR3001 | HEAR3003 | HEAR3001 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | 0.671 |
| lipA | HEAR3004 | HEAR3003 | HEAR3004 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Metabolite transport protein; Function of strongly homologous gene; transporter. | 0.639 |
| lipA | lipB | HEAR3003 | HEAR3002 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Lipoyl-[acyl-carrier-protein]-protein-N- lipoyltransferase (Lipoate-protein ligase B); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.999 |
| lipA | lpdA | HEAR3003 | HEAR0748 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Dihydrolipoyl dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.839 |
| lipA | nrdA | HEAR3003 | HEAR2770 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Ribonucleoside-diphosphate reductase alpha subunit (Ribonucleotide reductase); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.681 |
| lipA | obg | HEAR3003 | HEAR2785 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Conserved hypothetical protein, putative GTPase; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.500 |
| lipA | odhL | HEAR3003 | HEAR1770 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Dihydrolipoyl dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.647 |
| lipA | pdhB | HEAR3003 | HEAR0747 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.726 |
| lipA | sucB | HEAR3003 | HEAR1771 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.733 |
| lipB | HEAR3000 | HEAR3002 | HEAR3000 | Lipoyl-[acyl-carrier-protein]-protein-N- lipoyltransferase (Lipoate-protein ligase B); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | D-amino-acid transaminase; Function of strongly homologous gene; enzyme. | 0.714 |
| lipB | HEAR3001 | HEAR3002 | HEAR3001 | Lipoyl-[acyl-carrier-protein]-protein-N- lipoyltransferase (Lipoate-protein ligase B); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | 0.890 |
| lipB | lipA | HEAR3002 | HEAR3003 | Lipoyl-[acyl-carrier-protein]-protein-N- lipoyltransferase (Lipoate-protein ligase B); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.999 |
