| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HEAR3000 | HEAR3001 | HEAR3000 | HEAR3001 | D-amino-acid transaminase; Function of strongly homologous gene; enzyme. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | 0.867 |
| HEAR3000 | lipA | HEAR3000 | HEAR3003 | D-amino-acid transaminase; Function of strongly homologous gene; enzyme. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.545 |
| HEAR3000 | lipB | HEAR3000 | HEAR3002 | D-amino-acid transaminase; Function of strongly homologous gene; enzyme. | Lipoyl-[acyl-carrier-protein]-protein-N- lipoyltransferase (Lipoate-protein ligase B); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.680 |
| HEAR3000 | lpdA | HEAR3000 | HEAR0748 | D-amino-acid transaminase; Function of strongly homologous gene; enzyme. | Dihydrolipoyl dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.453 |
| HEAR3001 | HEAR3000 | HEAR3001 | HEAR3000 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | D-amino-acid transaminase; Function of strongly homologous gene; enzyme. | 0.867 |
| HEAR3001 | lipA | HEAR3001 | HEAR3003 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.623 |
| HEAR3001 | lipB | HEAR3001 | HEAR3002 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | Lipoyl-[acyl-carrier-protein]-protein-N- lipoyltransferase (Lipoate-protein ligase B); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.881 |
| HEAR3004 | lipA | HEAR3004 | HEAR3003 | Metabolite transport protein; Function of strongly homologous gene; transporter. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.639 |
| lipA | HEAR3000 | HEAR3003 | HEAR3000 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | D-amino-acid transaminase; Function of strongly homologous gene; enzyme. | 0.545 |
| lipA | HEAR3001 | HEAR3003 | HEAR3001 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | 0.623 |
| lipA | HEAR3004 | HEAR3003 | HEAR3004 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Metabolite transport protein; Function of strongly homologous gene; transporter. | 0.639 |
| lipA | lipB | HEAR3003 | HEAR3002 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Lipoyl-[acyl-carrier-protein]-protein-N- lipoyltransferase (Lipoate-protein ligase B); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.999 |
| lipA | lpdA | HEAR3003 | HEAR0748 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Dihydrolipoyl dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.776 |
| lipA | nrdA | HEAR3003 | HEAR2770 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Ribonucleoside-diphosphate reductase alpha subunit (Ribonucleotide reductase); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.670 |
| lipA | odhL | HEAR3003 | HEAR1770 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Dihydrolipoyl dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.653 |
| lipA | pdhB | HEAR3003 | HEAR0747 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.650 |
| lipA | sucB | HEAR3003 | HEAR1771 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.658 |
| lipA | tkt | HEAR3003 | HEAR0848 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Transketolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the transketolase family. | 0.502 |
| lipB | HEAR3000 | HEAR3002 | HEAR3000 | Lipoyl-[acyl-carrier-protein]-protein-N- lipoyltransferase (Lipoate-protein ligase B); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | D-amino-acid transaminase; Function of strongly homologous gene; enzyme. | 0.680 |
| lipB | HEAR3001 | HEAR3002 | HEAR3001 | Lipoyl-[acyl-carrier-protein]-protein-N- lipoyltransferase (Lipoate-protein ligase B); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | 0.881 |