STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EVG20_g3845Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (528 aa)    
Predicted Functional Partners:
EVG20_g6194
Pterin-binding domain-containing protein.
 
 
 0.945
EVG20_g414
Flavoprotein domain-containing protein.
     
 0.913
EVG20_g174
Mur_ligase_M domain-containing protein.
  
  
0.858
EVG20_g4933
Thymidylat_synt domain-containing protein.
     
 0.850
EVG20_g7921
Glutamine amidotransferase type-1 domain-containing protein.
     
 0.813
EVG20_g2903
Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.
  
 0.805
EVG20_g7293
Uncharacterized protein.
  
 
 0.790
EVG20_g657
Uncharacterized protein.
    
 0.774
EVG20_g4156
DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.
     
 0.755
EVG20_g8709
Uncharacterized protein.
    
 0.750
Your Current Organism:
Dentipellis fragilis
NCBI taxonomy Id: 205917
Other names: D. fragilis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.