EVG20_g755 protein (Dentipellis fragilis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EVG20_g755

Uncharacterized protein. (444 aa)

Predicted Functional Partners:

EVG20_g1256

0.702

EVG20_g104

0.684

EVG20_g4749

0.671

EVG20_g759

0.652

EVG20_g508

0.651

EVG20_g3738

0.636

EVG20_g4195

0.631

EVG20_g4710

0.589

EVG20_g3677

0.586

EVG20_g2680

0.581

Your Current Organism:

Dentipellis fragilis

NCBI taxonomy Id: 205917
Other names: D. fragilis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EVG20_g104	EVG20_g1256	A0A4Y9ZG81	A0A4Y9ZAG1	DNA polymerase.	Uncharacterized protein.	0.999
EVG20_g104	EVG20_g3677	A0A4Y9ZG81	A0A4Y9YZY5	DNA polymerase.	Uncharacterized protein.	0.894
EVG20_g104	EVG20_g4749	A0A4Y9ZG81	A0A4Y9YX57	DNA polymerase.	ERCC4 domain-containing protein.	0.753
EVG20_g104	EVG20_g755	A0A4Y9ZG81	A0A4Y9ZE49	DNA polymerase.	Uncharacterized protein.	0.684
EVG20_g1256	EVG20_g104	A0A4Y9ZAG1	A0A4Y9ZG81	Uncharacterized protein.	DNA polymerase.	0.999
EVG20_g1256	EVG20_g3677	A0A4Y9ZAG1	A0A4Y9YZY5	Uncharacterized protein.	Uncharacterized protein.	0.791
EVG20_g1256	EVG20_g755	A0A4Y9ZAG1	A0A4Y9ZE49	Uncharacterized protein.	Uncharacterized protein.	0.702
EVG20_g2680	EVG20_g4195	A0A4Y9Z786	A0A4Y9YWU4	Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site; Belongs to the snRNP core protein family.	Small nuclear ribonucleoprotein Sm D2.	0.999
EVG20_g2680	EVG20_g508	A0A4Y9Z786	A0A4Y9ZEV0	Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site; Belongs to the snRNP core protein family.	Sm domain-containing protein.	0.999
EVG20_g2680	EVG20_g755	A0A4Y9Z786	A0A4Y9ZE49	Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site; Belongs to the snRNP core protein family.	Uncharacterized protein.	0.581
EVG20_g2680	EVG20_g759	A0A4Y9Z786	A0A4Y9ZBM2	Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site; Belongs to the snRNP core protein family.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.999
EVG20_g3677	EVG20_g104	A0A4Y9YZY5	A0A4Y9ZG81	Uncharacterized protein.	DNA polymerase.	0.894
EVG20_g3677	EVG20_g1256	A0A4Y9YZY5	A0A4Y9ZAG1	Uncharacterized protein.	Uncharacterized protein.	0.791
EVG20_g3677	EVG20_g4749	A0A4Y9YZY5	A0A4Y9YX57	Uncharacterized protein.	ERCC4 domain-containing protein.	0.844
EVG20_g3677	EVG20_g755	A0A4Y9YZY5	A0A4Y9ZE49	Uncharacterized protein.	Uncharacterized protein.	0.586
EVG20_g3738	EVG20_g755	A0A4Y9YZH1	A0A4Y9ZE49	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.636
EVG20_g4195	EVG20_g2680	A0A4Y9YWU4	A0A4Y9Z786	Small nuclear ribonucleoprotein Sm D2.	Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site; Belongs to the snRNP core protein family.	0.999
EVG20_g4195	EVG20_g4710	A0A4Y9YWU4	A0A4Y9YVY1	Small nuclear ribonucleoprotein Sm D2.	Uncharacterized protein.	0.982
EVG20_g4195	EVG20_g508	A0A4Y9YWU4	A0A4Y9ZEV0	Small nuclear ribonucleoprotein Sm D2.	Sm domain-containing protein.	0.999
EVG20_g4195	EVG20_g755	A0A4Y9YWU4	A0A4Y9ZE49	Small nuclear ribonucleoprotein Sm D2.	Uncharacterized protein.	0.631

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Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.817

expected number of edges:

11

PPI enrichment p-value:

0.0668

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007264

Small GTPase mediated signal transduction

9 of 59

2.23

6.56

5.63e-16

GO:0060178

Regulation of exocyst localization

2 of 2

3.04

1.6

0.0013

GO:0045921

Positive regulation of exocytosis

2 of 2

3.04

1.6

0.0013

GO:0032488

Cdc42 protein signal transduction

2 of 2

3.04

1.6

0.0013

GO:0030307

Positive regulation of cell growth

2 of 3

2.87

1.53

0.0017

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003924

GTPase activity

8 of 145

1.78

3.6

1.27e-10

GO:0005525

GTP binding

8 of 187

1.67

3.16

4.55e-10

GO:0019003

GDP binding

3 of 10

2.52

2.45

2.63e-05

GO:0003925

G protein activity

3 of 10

2.52

2.45

2.63e-05

GO:0098772

Molecular function regulator activity

4 of 418

1.02

0.59

0.0267

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098852

Lytic vacuole membrane

5 of 98

1.75

2.27

4.71e-06

GO:0000322

Storage vacuole

5 of 116

1.68

2.11

7.95e-06

GO:0005886

Plasma membrane

9 of 486

1.31

1.95

1.18e-08

GO:0005940

Septin ring

2 of 20

2.04

0.99

0.0137

GO:0031965

Nuclear membrane

2 of 34

1.81

0.78

0.0308

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3750

Mixed, incl. Small GTPase mediated signal transduction, and Rho GTPase activation protein

11 of 138

1.94

6.0

1.18e-18

CL:3941

Mixed, incl. Ras-like guanine nucleotide exchange factor, and GDP binding

5 of 37

2.17

3.53

4.54e-08

CL:3772

Mixed, incl. Rho (Ras homology) subfamily of Ras-like small GTPases, and RasGAP C-terminus

4 of 18

2.39

3.23

5.31e-07

CL:3751

Mixed, incl. RHOV GTPase cycle, and RAC1 GTPase cycle

6 of 92

1.86

3.12

3.19e-08

CL:3753

Mixed, incl. RHOV GTPase cycle, and RAC1 GTPase cycle

5 of 76

1.86

2.64

9.43e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04145

Phagosome

3 of 70

1.67

1.11

0.0048

map04138

Autophagy - yeast

3 of 119

1.44

0.89

0.0111

map04113

Meiosis - yeast

3 of 148

1.35

0.81

0.0140

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5626467

RHO GTPases activate IQGAPs

5 of 9

2.79

5.3

9.84e-11

MAP-389359

CD28 dependent Vav1 pathway

5 of 13

2.63

4.97

2.80e-10

MAP-5627123

RHO GTPases activate PAKs

5 of 14

2.6

4.91

3.26e-10

MAP-389356

CD28 co-stimulation

5 of 19

2.46

4.55

1.04e-09

MAP-2029482

Regulation of actin dynamics for phagocytic cup formation

5 of 24

2.36

4.27

2.58e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005886

Plasma membrane

5 of 228

1.38

1.19

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0342

GTP-binding

8 of 90

1.99

4.85

5.46e-13

KW-0132

Cell division

3 of 28

2.07

1.86

0.00021

KW-0728

SH3 domain

3 of 67

1.69

1.33

0.0015

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001806

Small GTPase

8 of 55

2.21

5.64

1.86e-13

IPR005225

Small GTP-binding protein domain

8 of 76

2.07

5.0

1.04e-12

IPR003578

Small GTPase Rho

5 of 14

2.6

4.46

2.80e-09

IPR020849

Small GTPase, Ras-type

3 of 10

2.52

2.13

0.00011

IPR027417

P-loop containing nucleoside triphosphate hydrolase

8 of 504

1.24

1.57

1.21e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00174

Rho (Ras homology) subfamily of Ras-like small GTPases

5 of 13

2.63

4.78

6.75e-10

SM00173

Ras subfamily of RAS small GTPases

3 of 10

2.52

2.42

2.97e-05

SM00326

Src homology 3 domains

3 of 69

1.68

1.15

0.0040

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