Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ECH_0232Tim44-like domain protein; Identified by similarity to GB:AAS13862.1; match to protein family HMM PF04280. (212 aa)    
Predicted Functional Partners:
secB
Protein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.
 
     0.763
ECH_0199
Conserved hypothetical protein; Identified by similarity to PIR:G97712; match to protein family HMM PF06242.
  
     0.745
recO
Putative DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.
  
     0.720
ECH_0744
Conserved hypothetical protein; Identified by similarity to PIR:F71632; match to protein family HMM PF07031.
  
     0.715
ECH_0820
Conserved hypothetical protein; Identified by similarity to GB:AAS14586.1.
  
     0.689
ECH_0874
Disulfide bond formation family protein; Identified by match to protein family HMM PF02600.
  
     0.682
hemD
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
     0.638
ECH_0576
Conserved hypothetical protein; Identified by similarity to SP:O05113.
  
     0.638
yidC
Inner-membrane protein, 60 kDa; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
  
     0.618
ECH_0184
Identified by match to protein family HMM PF05071.
  
     0.611
Your Current Organism:
Ehrlichia chaffeensis
NCBI taxonomy Id: 205920
Other names: E. chaffeensis str. Arkansas, Ehrlichia chaffeensis Arkansas, Ehrlichia chaffeensis str. Arkansas
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