| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ECH_0039 | clpB | ECH_0039 | ECH_0367 | 120 kDa immunodominant surface protein; Identified by similarity to PIR:JC6174; match to protein family HMM TIGR02202. | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.712 |
| ECH_0039 | clpP | ECH_0039 | ECH_0901 | 120 kDa immunodominant surface protein; Identified by similarity to PIR:JC6174; match to protein family HMM TIGR02202. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.495 |
| ECH_0039 | dnaK | ECH_0039 | ECH_0471 | 120 kDa immunodominant surface protein; Identified by similarity to PIR:JC6174; match to protein family HMM TIGR02202. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.978 |
| ECH_0039 | groES | ECH_0039 | ECH_0364 | 120 kDa immunodominant surface protein; Identified by similarity to PIR:JC6174; match to protein family HMM TIGR02202. | Chaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.651 |
| ECH_0039 | grpE | ECH_0039 | ECH_0168 | 120 kDa immunodominant surface protein; Identified by similarity to PIR:JC6174; match to protein family HMM TIGR02202. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.905 |
| ECH_0039 | hscA | ECH_0039 | ECH_0633 | 120 kDa immunodominant surface protein; Identified by similarity to PIR:JC6174; match to protein family HMM TIGR02202. | Chaperone protein HscA; Identified by similarity to SP:P36541; match to protein family HMM PF00012; Belongs to the heat shock protein 70 family. | 0.978 |
| ECH_0039 | hslU | ECH_0039 | ECH_0997 | 120 kDa immunodominant surface protein; Identified by similarity to PIR:JC6174; match to protein family HMM TIGR02202. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. | 0.696 |
| ECH_0039 | htpG | ECH_0039 | ECH_0853 | 120 kDa immunodominant surface protein; Identified by similarity to PIR:JC6174; match to protein family HMM TIGR02202. | Chaperone protein HtpG; Molecular chaperone. Has ATPase activity. | 0.962 |
| ECH_0039 | lon | ECH_0039 | ECH_0899 | 120 kDa immunodominant surface protein; Identified by similarity to PIR:JC6174; match to protein family HMM TIGR02202. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.686 |
| clpB | ECH_0039 | ECH_0367 | ECH_0039 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 120 kDa immunodominant surface protein; Identified by similarity to PIR:JC6174; match to protein family HMM TIGR02202. | 0.712 |
| clpB | clpP | ECH_0367 | ECH_0901 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.912 |
| clpB | dnaJ | ECH_0367 | ECH_0025 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.835 |
| clpB | dnaK | ECH_0367 | ECH_0471 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.960 |
| clpB | groES | ECH_0367 | ECH_0364 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.705 |
| clpB | grpE | ECH_0367 | ECH_0168 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.868 |
| clpB | hscA | ECH_0367 | ECH_0633 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein HscA; Identified by similarity to SP:P36541; match to protein family HMM PF00012; Belongs to the heat shock protein 70 family. | 0.917 |
| clpB | hslU | ECH_0367 | ECH_0997 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. | 0.717 |
| clpB | htpG | ECH_0367 | ECH_0853 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein HtpG; Molecular chaperone. Has ATPase activity. | 0.855 |
| clpB | lon | ECH_0367 | ECH_0899 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.659 |
| clpP | ECH_0039 | ECH_0901 | ECH_0039 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 120 kDa immunodominant surface protein; Identified by similarity to PIR:JC6174; match to protein family HMM TIGR02202. | 0.495 |
