Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
qorQuinone oxidoreductase; Identified by similarity to SP:P28304; match to protein family HMM PF00107. (324 aa)    
Predicted Functional Partners:
ECH_0653
Ankyrin repeat protein; Identified by match to protein family HMM PF00023.
 
 
 
 0.613
ECH_0175
Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.
     
 0.579
ECH_0039
120 kDa immunodominant surface protein; Identified by similarity to PIR:JC6174; match to protein family HMM TIGR02202.
  
 
 0.519
ECH_0585
Conserved domain protein.
     
 0.482
ECH_0778
Conserved hypothetical protein; Identified by similarity to PIR:E97700; match to protein family HMM PF00175.
      
 0.466
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
   
   0.445
ECH_0201
dnaJ domain protein; Identified by match to protein family HMM PF00226.
   
   0.445
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 
 0.444
nuoM
NADH dehydrogenase I, M subunit; Identified by similarity to SP:P29925; match to protein family HMM PF00361; match to protein family HMM TIGR01972.
      
 0.439
ECH_0188
Putative surface protein; Identified by similarity to GB:AAD32553.1.
    
   0.438
Your Current Organism:
Ehrlichia chaffeensis
NCBI taxonomy Id: 205920
Other names: E. chaffeensis str. Arkansas, Ehrlichia chaffeensis Arkansas, Ehrlichia chaffeensis str. Arkansas
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.