STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sppASignal peptide peptidase SppA; Identified by match to protein family HMM PF01343; match to protein family HMM TIGR00706. (288 aa)    
Predicted Functional Partners:
ihfB
Integration host factor, beta subunit; Identified by similarity to SP:Q06607; match to protein family HMM PF00216; Belongs to the bacterial histone-like protein family.
  
    0.833
ECH_0402
Putative ribosomal protein S1; Identified by similarity to SP:P02349; match to protein family HMM PF00575.
       0.772
ECH_0398
Conserved hypothetical protein; Identified by similarity to GB:AAS14743.1.
       0.642
ECH_0399
Conserved hypothetical protein; Identified by similarity to GB:BAB50572.1.
       0.634
cmk
Cytidylate kinase; Identified by match to protein family HMM PF02224; match to protein family HMM TIGR00017.
       0.607
ECH_0404
RNA methyltransferase, TrmH family, group 3; Identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
       0.592
ECH_0332
HAD-superfamily hydrolase, subfamily IA, variant 1; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549.
  
  
 0.514
clpP
ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
      
 0.472
ECH_0836
Conserved hypothetical protein; Identified by similarity to GB:AAS14108.1.
   
  
 0.469
secY
Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
     
 0.404
Your Current Organism:
Ehrlichia chaffeensis
NCBI taxonomy Id: 205920
Other names: E. chaffeensis str. Arkansas, Ehrlichia chaffeensis Arkansas, Ehrlichia chaffeensis str. Arkansas
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.