Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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hemDuroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (229 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.994
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.948
hemB
Delta-aminolevulinic acid dehydratase; Identified by similarity to SP:P45622; match to protein family HMM PF00490; Belongs to the ALAD family.
  
 
 0.899
ECH_0126
Conserved hypothetical protein; Identified by similarity to GB:AAS14093.1; match to protein family HMM PF06144; match to protein family HMM TIGR01128.
 
     0.726
ECH_0820
Conserved hypothetical protein; Identified by similarity to GB:AAS14586.1.
  
     0.713
ECH_0907
Conserved hypothetical protein; Identified by similarity to GB:AAS14420.1.
  
     0.694
ECH_0232
Tim44-like domain protein; Identified by similarity to GB:AAS13862.1; match to protein family HMM PF04280.
  
     0.638
ccmC
Heme exporter protein CcmC; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
  
    0.607
ECH_0337
Putative cell division protein FtsQ; Essential cell division protein.
  
     0.595
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
  
 0.583
Your Current Organism:
Ehrlichia chaffeensis
NCBI taxonomy Id: 205920
Other names: E. chaffeensis str. Arkansas, Ehrlichia chaffeensis Arkansas, Ehrlichia chaffeensis str. Arkansas
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