Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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iscSCysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (410 aa)    
Predicted Functional Partners:
iscU
FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
 0.998
ECH_0628
Rrf2/aminotransferase, class V family protein; Identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM PF02082; match to protein family HMM TIGR00738.
 
 
0.993
ECH_0634
Iron-sulfur cluster binding protein; Identified by match to protein family HMM PF00111.
 
 0.977
hscB
Co-chaperone Hsc20; Identified by similarity to SP:P36540; match to protein family HMM PF00226; match to protein family HMM PF07743; Belongs to the HscB family.
  
 0.976
ECH_0631
Iron-sulfur cluster assembly accessory protein; Identified by match to protein family HMM PF01521; match to protein family HMM TIGR00049; Belongs to the HesB/IscA family.
  
 
 0.969
ECH_0312
cyaY protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
   
 0.885
hscA
Chaperone protein HscA; Identified by similarity to SP:P36541; match to protein family HMM PF00012; Belongs to the heat shock protein 70 family.
  
 0.814
ECH_0202
NifU domain protein; Identified by match to protein family HMM PF01106.
 
 
 0.786
thiF
Adenylyltransferase thiF; Identified by similarity to SP:P30138; match to protein family HMM PF00899; match to protein family HMM PF05237.
   
 0.761
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
    
 
 0.760
Your Current Organism:
Ehrlichia chaffeensis
NCBI taxonomy Id: 205920
Other names: E. chaffeensis str. Arkansas, Ehrlichia chaffeensis Arkansas, Ehrlichia chaffeensis str. Arkansas
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