STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucB2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (404 aa)    
Predicted Functional Partners:
sucA
2-oxoglutarate dehydrogenase, E1 component; Identified by match to protein family HMM PF00676; match to protein family HMM PF02779; match to protein family HMM TIGR00239.
 0.999
lpdA-1
Dihydrolipoamide dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350.
 0.997
lpdA-2
Dihydrolipoamide dehydrogenase; Identified by similarity to GB:AAA21748.1; match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350.
 0.997
ECH_0149
Putative pyruvate dehydrogenase complex, E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
 0.994
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.980
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.975
pdhA
Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.971
prsA
Ribose-phosphate pyrophosphokinase; Identified by similarity to SP:P08330; match to protein family HMM PF00156; match to protein family HMM TIGR01251.
   
 0.915
ECH_0755
Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518.
    
 0.831
ECH_0885
Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF02518.
    
 0.805
Your Current Organism:
Ehrlichia chaffeensis
NCBI taxonomy Id: 205920
Other names: E. chaffeensis str. Arkansas, Ehrlichia chaffeensis Arkansas, Ehrlichia chaffeensis str. Arkansas
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.