STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
putP_1Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (504 aa)    
Predicted Functional Partners:
rocA
1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family.
 
  
 0.971
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
  
 0.779
whiB4
Transcriptional regulator WhiB4; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
   
  
 0.766
cstA
Carbon starvation protein A.
 
    0.614
lexA
LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
   
  
 0.595
alsT
Amino-acid carrier protein AlsT.
  
  
 0.573
ykuT
Putative MscS family protein YkuT.
     
 0.553
gltC_2
HTH-type transcriptional regulator GltC; Belongs to the LysR transcriptional regulatory family.
       0.540
sdcS
Sodium-dependent dicarboxylate transporter SdcS.
 
  
 0.511
ctaC
Cytochrome c oxidase subunit 2 precursor.
   
  
 0.509
Your Current Organism:
Pseudonocardia autotrophica
NCBI taxonomy Id: 2074
Other names: ATCC 19727, Amycolata autotrophica, CIP 107114, DSM 535, IFO 12743, IMSNU 20050, JCM 4348, NBRC 12743, NRRL B-11275, Nocardia autotrophica, P. autotrophica, Streptomyces autotrophicus, VKM Ac-941
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