OSY39216.1 protein (Pseudonocardia autotrophica)

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

OSY39216.1

Transcriptional regulator BetI. (214 aa)

Predicted Functional Partners:

OSY39217.1

0.814

OSY42439.1

0.547

OSY41518.1

0.500

htpX_2

0.470

OSY36756.1

0.457

OSY43644.1

0.453

cocE

0.442

vapC3

0.441

OSY36675.1

0.416

Your Current Organism:

Pseudonocardia autotrophica

NCBI taxonomy Id: 2074
Other names: ATCC 19727, Amycolata autotrophica, CIP 107114, DSM 535, IFO 12743, IMSNU 20050, JCM 4348, NBRC 12743, NRRL B-11275, Nocardia autotrophica, P. autotrophica, Streptomyces autotrophicus, VKM Ac-941

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OSY36675.1	OSY39216.1	BG845_05280	BG845_03486	Bacterial regulatory proteins, tetR family.	Transcriptional regulator BetI.	0.416
OSY36756.1	OSY39216.1	BG845_05192	BG845_03486	Mycothiol-dependent maleylpyruvate isomerase.	Transcriptional regulator BetI.	0.457
OSY39216.1	OSY36675.1	BG845_03486	BG845_05280	Transcriptional regulator BetI.	Bacterial regulatory proteins, tetR family.	0.416
OSY39216.1	OSY36756.1	BG845_03486	BG845_05192	Transcriptional regulator BetI.	Mycothiol-dependent maleylpyruvate isomerase.	0.457
OSY39216.1	OSY39217.1	BG845_03486	BG845_03487	Transcriptional regulator BetI.	Short chain dehydrogenase.	0.814
OSY39216.1	OSY41518.1	BG845_03486	BG845_02009	Transcriptional regulator BetI.	Hypothetical protein.	0.500
OSY39216.1	OSY42439.1	BG845_03486	BG845_01359	Transcriptional regulator BetI.	Putative O-methyltransferase/MSMEI_4947.	0.547
OSY39216.1	OSY43644.1	BG845_03486	BG845_00590	Transcriptional regulator BetI.	Bacterial regulatory proteins, tetR family.	0.453
OSY39216.1	cocE	BG845_03486	BG845_02260	Transcriptional regulator BetI.	Cocaine esterase.	0.442
OSY39216.1	htpX_2	BG845_03486	BG845_05242	Transcriptional regulator BetI.	Protease HtpX.	0.470
OSY39216.1	vapC3	BG845_03486	BG845_06741	Transcriptional regulator BetI.	Ribonuclease VapC3; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family.	0.441
OSY39217.1	OSY39216.1	BG845_03487	BG845_03486	Short chain dehydrogenase.	Transcriptional regulator BetI.	0.814
OSY41518.1	OSY39216.1	BG845_02009	BG845_03486	Hypothetical protein.	Transcriptional regulator BetI.	0.500
OSY42439.1	OSY39216.1	BG845_01359	BG845_03486	Putative O-methyltransferase/MSMEI_4947.	Transcriptional regulator BetI.	0.547
OSY43644.1	OSY39216.1	BG845_00590	BG845_03486	Bacterial regulatory proteins, tetR family.	Transcriptional regulator BetI.	0.453
cocE	OSY39216.1	BG845_02260	BG845_03486	Cocaine esterase.	Transcriptional regulator BetI.	0.442
htpX_2	OSY39216.1	BG845_05242	BG845_03486	Protease HtpX.	Transcriptional regulator BetI.	0.470
vapC3	OSY39216.1	BG845_06741	BG845_03486	Ribonuclease VapC3; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family.	Transcriptional regulator BetI.	0.441

Network Stats

number of nodes:

11

number of edges:

48

average node degree:

8.73

avg. local clustering coefficient:

0.915

expected number of edges:

13

PPI enrichment p-value:

3.57e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007059

Chromosome segregation

9 of 76

2.24

6.67

3.63e-16

GO:0000819

Sister chromatid segregation

7 of 38

2.43

6.07

2.90e-13

GO:0000070

Mitotic sister chromatid segregation

6 of 34

2.41

5.21

2.64e-11

GO:0000280

Nuclear division

7 of 77

2.13

4.8

1.23e-11

GO:1903047

Mitotic cell cycle process

8 of 161

1.86

4.1

1.08e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035174

Histone serine kinase activity

2 of 2

3.17

1.98

0.00027

GO:0140657

ATP-dependent activity

6 of 456

1.29

1.39

4.80e-05

GO:0016887

ATP hydrolysis activity

4 of 242

1.39

1.15

0.0014

GO:0005524

ATP binding

8 of 1002

1.07

1.09

4.80e-05

GO:0003697

Single-stranded DNA binding

2 of 32

1.96

0.96

0.0145

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044815

DNA packaging complex

5 of 55

2.13

3.44

5.40e-08

GO:0000793

Condensed chromosome

5 of 55

2.13

3.44

5.40e-08

GO:0000796

Condensin complex

3 of 3

3.17

3.42

6.25e-07

GO:0005694

Chromosome

9 of 341

1.59

3.09

4.01e-11

GO:0005876

Spindle microtubule

3 of 10

2.64

2.75

7.64e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14064

SUMOylation of DNA damage response and repair proteins, and Condensin complex

7 of 20

2.71

7.18

9.89e-15

CL:14065

Cohesin complex, and Condensin complex

5 of 11

2.82

5.15

2.12e-10

CL:14068

Cohesin complex

2 of 5

2.77

1.47

0.0021

CL:10128

Chromosome passenger complex, and Transposon, En/Spm-like

2 of 5

2.77

1.47

0.0021

CL:14089

Smc5-Smc6 complex

2 of 6

2.69

1.45

0.0023

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04111

Cell cycle - yeast

5 of 131

1.75

2.35

2.52e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3108214

SUMOylation of DNA damage response and repair proteins

4 of 18

2.51

3.44

2.66e-07

MAP-68877

Mitotic Prometaphase

5 of 53

2.14

3.3

1.31e-07

MAP-3108232

SUMO E3 ligases SUMOylate target proteins

5 of 87

1.93

2.81

5.68e-07

MAP-2514853

Condensation of Prometaphase Chromosomes

3 of 12

2.56

2.59

1.43e-05

MAP-69278

Cell Cycle, Mitotic

7 of 274

1.57

2.4

1.31e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000793

Condensed chromosome

7 of 110

1.97

4.01

2.49e-10

GOCC:0005694

Chromosome

9 of 491

1.43

2.46

3.06e-10

GOCC:0000796

Condensin complex

2 of 2

3.17

1.91

0.00035

GOCC:0043232

Intracellular non-membrane-bounded organelle

11 of 1152

1.15

1.65

2.49e-10

GOCC:0030915

Smc5-Smc6 complex

2 of 5

2.77

1.62

0.0011

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0226

DNA condensation

2 of 2

3.17

1.78

0.00062

KW-0498

Mitosis

2 of 4

2.87

1.71

0.00078

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13476

AAA domain

4 of 4

3.17

4.4

9.43e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036277

SMCs flexible hinge superfamily

3 of 3

3.17

2.65

1.57e-05

IPR003395

RecF/RecN/SMC, N-terminal

3 of 3

3.17

2.65

1.57e-05

IPR024704

Structural maintenance of chromosomes protein

2 of 2

3.17

1.42

0.0028

IPR010935

SMCs flexible hinge

2 of 2

3.17

1.42

0.0028

IPR030616

Aurora kinase-like

2 of 3

2.99

1.41

0.0028

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00968

SMC proteins Flexible Hinge Domain

2 of 2

3.17

1.69

0.00091

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