STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
gcvPAGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (443 aa)    
Predicted Functional Partners:
Dde_1691
PFAM: Glycine cleavage system P-protein, N-terminal; KEGG: dvm:DvMF_0223 glycine dehydrogenase subunit 2.
 0.999
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.999
Dde_1996
TIGRFAM: Glycine cleavage system T protein; KEGG: dvl:Dvul_1403 glycine cleavage system T protein; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel.
 
 0.999
Dde_1690
Dihydrolipoyl dehydrogenase; KEGG: dvl:Dvul_1653 FAD-dependent pyridine nucleotide-disulfide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulfide oxidoreductase; Pyridine nucleotide-disulfide oxidoreductase, NAD-binding region; Pyridine nucleotide-disulfide oxidoreductase, dimerisation.
 
 
 0.991
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.971
Dde_1657
KEGG: dvm:DvMF_0572 threonine aldolase; PFAM: Aromatic amino acid beta-eliminating lyase/threonine aldolase.
    
 0.924
Dde_1764
KEGG: dvm:DvMF_0434 phosphoribosylformylglycinamidine synthase.
  
 
  0.859
Dde_0104
TIGRFAM: Glutamine synthetase type I; KEGG: dvm:DvMF_2099 glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic region; Glutamine synthetase, beta-Grasp.
   
 
 0.834
Dde_1382
KEGG: dvl:Dvul_2024 Glu/Leu/Phe/Val dehydrogenase, C terminal; PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Bacterial NAD-glutamate dehydrogenase; SMART: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal.
   
 
 0.829
Dde_0054
Proline dehydrogenase / 1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family.
   
 
 0.818
Your Current Organism:
Desulfovibrio alaskensis
NCBI taxonomy Id: 207559
Other names: D. alaskensis G20, Desulfovibrio alaskensis G20, Desulfovibrio alaskensis str. G20, Desulfovibrio alaskensis strain G20, Desulfovibrio desulfuricans subsp. desulfuricans str. G20
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