node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAT11376.1 | HemB | RED65_05652 | RED65_05647 | COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism. | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.584 |
EAT11376.1 | ppk | RED65_05652 | RED65_05642 | COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.403 |
EAT11385.1 | HemB | RED65_05697 | RED65_05647 | uroporphyrinogen-III synthetase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.881 |
EAT11385.1 | cysG | RED65_05697 | RED65_01565 | uroporphyrinogen-III synthetase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrin-III C-methyltransferase-like protein; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.970 |
EAT11385.1 | hemA | RED65_05697 | RED65_12309 | uroporphyrinogen-III synthetase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.666 |
EAT11385.1 | hemC | RED65_05697 | RED65_05702 | uroporphyrinogen-III synthetase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.998 |
EAT11385.1 | hemE | RED65_05697 | RED65_16301 | uroporphyrinogen-III synthetase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.945 |
EAT11385.1 | hemL | RED65_05697 | RED65_11802 | uroporphyrinogen-III synthetase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamate-1-semialdehyde-2,1-aminomutase; COG0001 Glutamate-1-semialdehyde aminotransferase. | 0.487 |
FabD | HemB | RED65_01170 | RED65_05647 | COG0331 (acyl-carrier-protein) S-malonyltransferase. | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.588 |
FabD | hemL | RED65_01170 | RED65_11802 | COG0331 (acyl-carrier-protein) S-malonyltransferase. | Glutamate-1-semialdehyde-2,1-aminomutase; COG0001 Glutamate-1-semialdehyde aminotransferase. | 0.811 |
HemB | EAT11376.1 | RED65_05647 | RED65_05652 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism. | 0.584 |
HemB | EAT11385.1 | RED65_05647 | RED65_05697 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrinogen-III synthetase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.881 |
HemB | FabD | RED65_05647 | RED65_01170 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | COG0331 (acyl-carrier-protein) S-malonyltransferase. | 0.588 |
HemB | atpD | RED65_05647 | RED65_08469 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. | 0.738 |
HemB | cysG | RED65_05647 | RED65_01565 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrin-III C-methyltransferase-like protein; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.930 |
HemB | hemA | RED65_05647 | RED65_12309 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.886 |
HemB | hemC | RED65_05647 | RED65_05702 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
HemB | hemE | RED65_05647 | RED65_16301 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.789 |
HemB | hemL | RED65_05647 | RED65_11802 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Glutamate-1-semialdehyde-2,1-aminomutase; COG0001 Glutamate-1-semialdehyde aminotransferase. | 0.994 |
HemB | ppk | RED65_05647 | RED65_05642 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.632 |