EAT13832.1 protein (Bermanella marisrubri) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

EAT13832.1

Response regulator containing a CheY-like receiver domain and a GGDEF domain; COG2199 FOG: GGDEF domain. (375 aa)

Predicted Functional Partners:

EAT12600.1

0.963

EAT12983.1

0.963

EAT11365.1

0.962

EAT13337.1

0.942

EAT10741.1

0.936

EAT11219.1

0.926

EAT11829.1

0.907

EAT11357.1

0.901

EAT10714.1

0.888

EAT13220.1

0.888

Your Current Organism:

Bermanella marisrubri

NCBI taxonomy Id: 207949
Other names: B. marisrubri, Bermanella marisrubri Pinhassi et al. 2009, CCUG 52064, CECT 7074, Oceanobacter sp. RED65, strain RED65

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAT10714.1	EAT10741.1	RED65_00015	RED65_03840	Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine; COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.969
EAT10714.1	EAT11219.1	RED65_00015	RED65_07319	Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine; COG0642 Signal transduction histidine kinase.	Type IV pilus response regulator Pilh; COG0784 FOG: CheY-like receiver.	0.767
EAT10714.1	EAT11357.1	RED65_00015	RED65_13057	Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine; COG0642 Signal transduction histidine kinase.	Hypothetical protein; COG2203 FOG: GAF domain.	0.540
EAT10714.1	EAT11365.1	RED65_00015	RED65_13097	Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine; COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.973
EAT10714.1	EAT12600.1	RED65_00015	RED65_06883	Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine; COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.972
EAT10714.1	EAT12983.1	RED65_00015	RED65_14842	Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine; COG0642 Signal transduction histidine kinase.	Putative sensor protein; COG0642 Signal transduction histidine kinase.	0.973
EAT10714.1	EAT13220.1	RED65_00015	RED65_00630	Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine; COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.968
EAT10714.1	EAT13337.1	RED65_00015	RED65_01215	Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine; COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.971
EAT10714.1	EAT13832.1	RED65_00015	RED65_10579	Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine; COG0642 Signal transduction histidine kinase.	Response regulator containing a CheY-like receiver domain and a GGDEF domain; COG2199 FOG: GGDEF domain.	0.888
EAT10741.1	EAT10714.1	RED65_03840	RED65_00015	COG0642 Signal transduction histidine kinase.	Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine; COG0642 Signal transduction histidine kinase.	0.969
EAT10741.1	EAT11219.1	RED65_03840	RED65_07319	COG0642 Signal transduction histidine kinase.	Type IV pilus response regulator Pilh; COG0784 FOG: CheY-like receiver.	0.497
EAT10741.1	EAT11357.1	RED65_03840	RED65_13057	COG0642 Signal transduction histidine kinase.	Hypothetical protein; COG2203 FOG: GAF domain.	0.501
EAT10741.1	EAT11365.1	RED65_03840	RED65_13097	COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.975
EAT10741.1	EAT11829.1	RED65_03840	RED65_05564	COG0642 Signal transduction histidine kinase.	Hypothetical protein; COG2202 FOG: PAS/PAC domain.	0.434
EAT10741.1	EAT12600.1	RED65_03840	RED65_06883	COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.975
EAT10741.1	EAT12983.1	RED65_03840	RED65_14842	COG0642 Signal transduction histidine kinase.	Putative sensor protein; COG0642 Signal transduction histidine kinase.	0.975
EAT10741.1	EAT13220.1	RED65_03840	RED65_00630	COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.970
EAT10741.1	EAT13337.1	RED65_03840	RED65_01215	COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.973
EAT10741.1	EAT13832.1	RED65_03840	RED65_10579	COG0642 Signal transduction histidine kinase.	Response regulator containing a CheY-like receiver domain and a GGDEF domain; COG2199 FOG: GGDEF domain.	0.936
EAT11219.1	EAT10714.1	RED65_07319	RED65_00015	Type IV pilus response regulator Pilh; COG0784 FOG: CheY-like receiver.	Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine; COG0642 Signal transduction histidine kinase.	0.767

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

35

PPI enrichment p-value:

0.000353

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

6 of 18

1.93

3.08

9.56e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004312

Fatty acid synthase activity

5 of 7

2.26

3.4

1.46e-07

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

3 of 4

2.28

1.85

0.00031

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1004

Fatty acid biosynthesis, and Phosphopantetheine

11 of 27

2.02

6.53

3.01e-19

CL:1006

Phosphopantetheine, and Fatty acid synthase activity

9 of 18

2.11

6.03

1.14e-15

CL:1026

Fatty acid synthase activity

5 of 7

2.26

3.85

1.34e-08

CL:1010

Phosphopantetheine

4 of 6

2.23

2.95

1.30e-06

CL:1045

acetyl-CoA carboxylase complex, and Biotin-binding site

2 of 6

1.93

0.92

0.0176

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00061

Fatty acid biosynthesis

6 of 17

1.95

3.5

7.33e-09

map01212

Fatty acid metabolism

6 of 24

1.81

3.07

2.13e-08

map00780

Biotin metabolism

3 of 7

2.04

1.86

0.00020

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009317

acetyl-CoA carboxylase complex

2 of 6

1.93

0.79

0.0320

GOCC:0032991

Protein-containing complex

7 of 343

0.72

0.49

0.0114

GOCC:0005622

Intracellular

11 of 929

0.48

0.39

0.0014

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

4 of 8

2.11

2.44

1.17e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00550

Phosphopantetheine attachment site

4 of 8

2.11

2.31

2.29e-05

PF02801

Beta-ketoacyl synthase, C-terminal domain

3 of 4

2.28

1.86

0.00029

PF00109

Beta-ketoacyl synthase, N-terminal domain

3 of 5

2.19

1.82

0.00031

PF00668

Condensation domain

3 of 6

2.11

1.78

0.00034

PF00501

AMP-binding enzyme

3 of 11

1.84

1.43

0.0012

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

4 of 8

2.11

6.44e-05

IPR009081

Phosphopantetheine binding ACP domain

4 of 8

2.11

6.44e-05

IPR016039

Thiolase-like

4 of 10

2.01

2.06

6.44e-05

IPR020841

Polyketide synthase, beta-ketoacyl synthase domain

3 of 4

2.28

1.79

0.00040

IPR014031

Beta-ketoacyl synthase, C-terminal

3 of 4

2.28

1.79

0.00040

(more ...)

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