node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAT11727.1 | EAT12341.1 | RED65_06252 | RED65_15918 | COG0460 Homoserine dehydrogenase. | COG2873 O-acetylhomoserine sulfhydrylase. | 0.868 |
EAT11727.1 | ThrH | RED65_06252 | RED65_07099 | COG0460 Homoserine dehydrogenase. | Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; COG0560 Phosphoserine phosphatase. | 0.918 |
EAT11727.1 | ilvA | RED65_06252 | RED65_12762 | COG0460 Homoserine dehydrogenase. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.630 |
EAT11727.1 | metXS | RED65_06252 | RED65_15077 | COG0460 Homoserine dehydrogenase. | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.967 |
EAT11727.1 | metZ | RED65_06252 | RED65_09124 | COG0460 Homoserine dehydrogenase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.931 |
EAT12341.1 | EAT11727.1 | RED65_15918 | RED65_06252 | COG2873 O-acetylhomoserine sulfhydrylase. | COG0460 Homoserine dehydrogenase. | 0.868 |
EAT12341.1 | ThrH | RED65_15918 | RED65_07099 | COG2873 O-acetylhomoserine sulfhydrylase. | Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; COG0560 Phosphoserine phosphatase. | 0.800 |
EAT12341.1 | ilvA | RED65_15918 | RED65_12762 | COG2873 O-acetylhomoserine sulfhydrylase. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.809 |
EAT12341.1 | metXS | RED65_15918 | RED65_15077 | COG2873 O-acetylhomoserine sulfhydrylase. | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.989 |
EAT12341.1 | metZ | RED65_15918 | RED65_09124 | COG2873 O-acetylhomoserine sulfhydrylase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.939 |
MetW | metXS | RED65_15082 | RED65_15077 | Methionine biosynthesis protein MetW; COG0500 SAM-dependent methyltransferases. | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.998 |
SerB | ThrH | RED65_14237 | RED65_07099 | Phosphoserine phosphatase SerB; COG3830 ACT domain-containing protein. | Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; COG0560 Phosphoserine phosphatase. | 0.915 |
SerB | glyA | RED65_14237 | RED65_16271 | Phosphoserine phosphatase SerB; COG3830 ACT domain-containing protein. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.945 |
SerB | ilvA | RED65_14237 | RED65_12762 | Phosphoserine phosphatase SerB; COG3830 ACT domain-containing protein. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.913 |
SerB | metXS | RED65_14237 | RED65_15077 | Phosphoserine phosphatase SerB; COG3830 ACT domain-containing protein. | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.805 |
SerB | trpA | RED65_14237 | RED65_09149 | Phosphoserine phosphatase SerB; COG3830 ACT domain-containing protein. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.903 |
SerB | trpB | RED65_14237 | RED65_06072 | Phosphoserine phosphatase SerB; COG3830 ACT domain-containing protein. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.918 |
ThrH | EAT11727.1 | RED65_07099 | RED65_06252 | Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; COG0560 Phosphoserine phosphatase. | COG0460 Homoserine dehydrogenase. | 0.918 |
ThrH | EAT12341.1 | RED65_07099 | RED65_15918 | Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; COG0560 Phosphoserine phosphatase. | COG2873 O-acetylhomoserine sulfhydrylase. | 0.800 |
ThrH | SerB | RED65_07099 | RED65_14237 | Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; COG0560 Phosphoserine phosphatase. | Phosphoserine phosphatase SerB; COG3830 ACT domain-containing protein. | 0.915 |