node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAT10667.1 | Lon | RED65_16676 | RED65_16681 | Hypothetical protein. | Lon protease; COG0466 ATP-dependent Lon protease, bacterial type. | 0.842 |
EAT10667.1 | TssH | RED65_16676 | RED65_00780 | Hypothetical protein. | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.549 |
EAT10667.1 | dnaJ | RED65_16676 | RED65_13502 | Hypothetical protein. | DnaJ-class molecular chaperone; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between [...] | 0.771 |
EAT10667.1 | dnaK | RED65_16676 | RED65_13497 | Hypothetical protein. | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.605 |
EAT10667.1 | ftsH | RED65_16676 | RED65_04775 | Hypothetical protein. | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.578 |
EAT10667.1 | groL | RED65_16676 | RED65_03235 | Hypothetical protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.772 |
EAT10667.1 | grpE | RED65_16676 | RED65_13492 | Hypothetical protein. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.767 |
EAT10667.1 | hslU | RED65_16676 | RED65_15973 | Hypothetical protein. | ATP-dependent protease ATP-binding subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.772 |
EAT10667.1 | hslV | RED65_16676 | RED65_15968 | Hypothetical protein. | ATP-dependent protease peptidase subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.760 |
EAT10667.1 | htpG | RED65_16676 | RED65_00650 | Hypothetical protein. | Heat shock protein 90; Molecular chaperone. Has ATPase activity. | 0.754 |
Lon | EAT10667.1 | RED65_16681 | RED65_16676 | Lon protease; COG0466 ATP-dependent Lon protease, bacterial type. | Hypothetical protein. | 0.842 |
Lon | TssH | RED65_16681 | RED65_00780 | Lon protease; COG0466 ATP-dependent Lon protease, bacterial type. | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.549 |
Lon | dnaJ | RED65_16681 | RED65_13502 | Lon protease; COG0466 ATP-dependent Lon protease, bacterial type. | DnaJ-class molecular chaperone; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between [...] | 0.797 |
Lon | dnaK | RED65_16681 | RED65_13497 | Lon protease; COG0466 ATP-dependent Lon protease, bacterial type. | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.659 |
Lon | ftsH | RED65_16681 | RED65_04775 | Lon protease; COG0466 ATP-dependent Lon protease, bacterial type. | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.636 |
Lon | groL | RED65_16681 | RED65_03235 | Lon protease; COG0466 ATP-dependent Lon protease, bacterial type. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.772 |
Lon | grpE | RED65_16681 | RED65_13492 | Lon protease; COG0466 ATP-dependent Lon protease, bacterial type. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.797 |
Lon | hslU | RED65_16681 | RED65_15973 | Lon protease; COG0466 ATP-dependent Lon protease, bacterial type. | ATP-dependent protease ATP-binding subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.772 |
Lon | hslV | RED65_16681 | RED65_15968 | Lon protease; COG0466 ATP-dependent Lon protease, bacterial type. | ATP-dependent protease peptidase subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.760 |
Lon | htpG | RED65_16681 | RED65_00650 | Lon protease; COG0466 ATP-dependent Lon protease, bacterial type. | Heat shock protein 90; Molecular chaperone. Has ATPase activity. | 0.754 |