EAR61678.1 protein (Neptuniibacter caesariensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EAR61678.1

Rhodanese-like protein; COG0607 Rhodanese-related sulfurtransferase. (213 aa)

Predicted Functional Partners:

EAR61149.1

0.888

EAR63003.1

0.879

EAR59470.1

0.848

EAR60693.1

0.824

EAR60443.1

0.818

EAR61503.1

0.806

EAR60697.1

0.805

EAR61485.1

0.801

EAR59646.1

0.786

EAR60691.1

0.777

Your Current Organism:

Neptuniibacter caesariensis

NCBI taxonomy Id: 207954
Other names: CCUG 52065, CECT 7075, N. caesariensis, Neptuniibacter caesariensis Arahal et al. 2007, Oceanospirillum sp. MED92, strain MED92

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAR59470.1	EAR59646.1	MED92_18478	MED92_04542	COG0186 Ribosomal protein S17.	COG0080 Ribosomal protein L11.	0.996
EAR59470.1	EAR60443.1	MED92_18478	MED92_08941	COG0186 Ribosomal protein S17.	soxH protein-like; COG0491 Zn-dependent hydrolases, including glyoxylases.	0.501
EAR59470.1	EAR61149.1	MED92_18478	MED92_04824	COG0186 Ribosomal protein S17.	COG0605 Superoxide dismutase.	0.955
EAR59470.1	EAR61485.1	MED92_18478	MED92_18303	COG0186 Ribosomal protein S17.	COG0261 Ribosomal protein L21.	0.995
EAR59470.1	EAR61503.1	MED92_18478	MED92_18393	COG0186 Ribosomal protein S17.	COG0203 Ribosomal protein L17.	0.997
EAR59470.1	EAR61678.1	MED92_18478	MED92_03747	COG0186 Ribosomal protein S17.	Rhodanese-like protein; COG0607 Rhodanese-related sulfurtransferase.	0.848
EAR59470.1	EAR63003.1	MED92_18478	MED92_07786	COG0186 Ribosomal protein S17.	Hypothetical protein; COG0319 Predicted metal-dependent hydrolase.	0.940
EAR59646.1	EAR59470.1	MED92_04542	MED92_18478	COG0080 Ribosomal protein L11.	COG0186 Ribosomal protein S17.	0.996
EAR59646.1	EAR61149.1	MED92_04542	MED92_04824	COG0080 Ribosomal protein L11.	COG0605 Superoxide dismutase.	0.948
EAR59646.1	EAR61485.1	MED92_04542	MED92_18303	COG0080 Ribosomal protein L11.	COG0261 Ribosomal protein L21.	0.996
EAR59646.1	EAR61503.1	MED92_04542	MED92_18393	COG0080 Ribosomal protein L11.	COG0203 Ribosomal protein L17.	0.996
EAR59646.1	EAR61678.1	MED92_04542	MED92_03747	COG0080 Ribosomal protein L11.	Rhodanese-like protein; COG0607 Rhodanese-related sulfurtransferase.	0.786
EAR59646.1	EAR63003.1	MED92_04542	MED92_07786	COG0080 Ribosomal protein L11.	Hypothetical protein; COG0319 Predicted metal-dependent hydrolase.	0.936
EAR60443.1	EAR59470.1	MED92_08941	MED92_18478	soxH protein-like; COG0491 Zn-dependent hydrolases, including glyoxylases.	COG0186 Ribosomal protein S17.	0.501
EAR60443.1	EAR60691.1	MED92_08941	MED92_13488	soxH protein-like; COG0491 Zn-dependent hydrolases, including glyoxylases.	Sulfur oxidation protein SoxB; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases.	0.774
EAR60443.1	EAR60693.1	MED92_08941	MED92_13498	soxH protein-like; COG0491 Zn-dependent hydrolases, including glyoxylases.	Sulfur oxidation protein SoxA; COG3258 Cytochrome c.	0.714
EAR60443.1	EAR61678.1	MED92_08941	MED92_03747	soxH protein-like; COG0491 Zn-dependent hydrolases, including glyoxylases.	Rhodanese-like protein; COG0607 Rhodanese-related sulfurtransferase.	0.818
EAR60443.1	EAR63003.1	MED92_08941	MED92_07786	soxH protein-like; COG0491 Zn-dependent hydrolases, including glyoxylases.	Hypothetical protein; COG0319 Predicted metal-dependent hydrolase.	0.586
EAR60691.1	EAR60443.1	MED92_13488	MED92_08941	Sulfur oxidation protein SoxB; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases.	soxH protein-like; COG0491 Zn-dependent hydrolases, including glyoxylases.	0.774
EAR60691.1	EAR60693.1	MED92_13488	MED92_13498	Sulfur oxidation protein SoxB; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases.	Sulfur oxidation protein SoxA; COG3258 Cytochrome c.	0.968

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.927

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

11 of 22

2.47

10.23

1.05e-23

GO:0051085

Chaperone cofactor-dependent protein refolding

6 of 6

2.77

6.09

2.47e-12

GO:0009408

Response to heat

5 of 6

2.69

4.91

4.47e-10

GO:0042026

Protein refolding

4 of 5

2.68

3.79

7.58e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051082

Unfolded protein binding

10 of 14

2.63

10.25

3.83e-22

GO:0140662

ATP-dependent protein folding chaperone

8 of 11

2.63

8.12

4.48e-17

GO:0051087

Chaperone binding

3 of 3

2.77

3.04

2.44e-06

GO:0031072

Heat shock protein binding

2 of 2

2.77

1.83

0.00046

GO:0030554

Adenyl nucleotide binding

11 of 487

1.13

1.63

6.29e-11

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990220

GroEL-GroES complex

3 of 3

2.77

2.87

5.00e-06

GO:0005829

Cytosol

5 of 344

0.94

0.71

0.0035

GO:0005737

Cytoplasm

11 of 1358

0.68

0.64

4.68e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1148

Unfolded protein binding, and ClpA/B, conserved site 1

11 of 17

2.58

11.08

1.20e-24

CL:1151

Unfolded protein binding

10 of 12

2.69

10.81

5.90e-23

CL:1165

De novo post-translational protein folding

5 of 5

2.77

5.12

2.16e-10

CL:1153

Heat shock protein 70kD, peptide-binding domain superfamily, and Chaperone DnaJ, C-terminal

5 of 6

2.69

4.97

3.45e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pls03018

RNA degradation

5 of 20

2.17

3.61

2.79e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990220

GroEL-GroES complex

3 of 3

2.77

2.57

1.86e-05

GOCC:0005737

Cytoplasm

7 of 1060

0.59

0.38

0.0288

GOCC:0110165

Cellular anatomical entity

11 of 3202

0.31

0.25

0.0266

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0143

Chaperone

9 of 15

2.55

8.86

2.52e-19

KW-0346

Stress response

3 of 6

2.47

2.49

2.07e-05

KW-0963

Cytoplasm

7 of 234

1.25

1.53

2.60e-06

KW-0067

ATP-binding

5 of 300

0.99

0.74

0.0041

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00118

TCP-1/cpn60 chaperonin family

3 of 3

2.77

2.35

4.81e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037124

GroES chaperonin superfamily

3 of 3

2.77

2.14

0.00012

IPR027413

GroEL-like equatorial domain superfamily

3 of 3

2.77

2.14

0.00012

IPR027410

TCP-1-like chaperonin intermediate domain superfamily

3 of 3

2.77

2.14

0.00012

IPR027409

GroEL-like apical domain superfamily

3 of 3

2.77

2.14

0.00012

IPR020818

GroES chaperonin family

3 of 3

2.77

2.14

0.00012

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00883

Chaperonin 10 Kd subunit

3 of 3

2.77

2.74

8.93e-06

SM00271

DnaJ molecular chaperone homology domain

2 of 3

2.6

1.53

0.0016

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About