EAR60126.1 protein (Neptuniibacter caesariensis)

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

EAR60126.1

COG2331 Uncharacterized protein conserved in bacteria. (76 aa)

Predicted Functional Partners:

EAR60127.1

0.674

EAR60137.1

0.504

EAR62178.1

0.494

EAR60125.1

0.492

EAR60128.1

0.454

EAR60139.1

0.433

ruvC

0.429

EAR60131.1

0.421

Your Current Organism:

Neptuniibacter caesariensis

NCBI taxonomy Id: 207954
Other names: CCUG 52065, CECT 7075, N. caesariensis, Neptuniibacter caesariensis Arahal et al. 2007, Oceanospirillum sp. MED92, strain MED92

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAR60125.1	EAR60126.1	MED92_08717	MED92_08722	Hypothetical protein; COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases.	COG2331 Uncharacterized protein conserved in bacteria.	0.492
EAR60126.1	EAR60125.1	MED92_08722	MED92_08717	COG2331 Uncharacterized protein conserved in bacteria.	Hypothetical protein; COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases.	0.492
EAR60126.1	EAR60127.1	MED92_08722	MED92_08727	COG2331 Uncharacterized protein conserved in bacteria.	COG0173 Aspartyl-tRNA synthetase.	0.674
EAR60126.1	EAR60128.1	MED92_08722	MED92_08732	COG2331 Uncharacterized protein conserved in bacteria.	Hypothetical protein.	0.454
EAR60126.1	EAR60131.1	MED92_08722	MED92_08747	COG2331 Uncharacterized protein conserved in bacteria.	COG0632 Holliday junction resolvasome, DNA-binding subunit.	0.421
EAR60126.1	EAR60137.1	MED92_08722	MED92_08777	COG2331 Uncharacterized protein conserved in bacteria.	TolB, N-terminal:TolB, N-terminal; COG0823 Periplasmic component of the Tol biopolymer transport system.	0.504
EAR60126.1	EAR60139.1	MED92_08722	MED92_08787	COG2331 Uncharacterized protein conserved in bacteria.	COG1729 Uncharacterized protein conserved in bacteria.	0.433
EAR60126.1	EAR62178.1	MED92_08722	MED92_10744	COG2331 Uncharacterized protein conserved in bacteria.	Periplasmic chaperone LolA; COG2834 Outer membrane lipoprotein-sorting protein.	0.494
EAR60126.1	ruvC	MED92_08722	MED92_08737	COG2331 Uncharacterized protein conserved in bacteria.	COG0817 Holliday junction resolvasome, endonuclease subunit.	0.429
EAR60127.1	EAR60126.1	MED92_08727	MED92_08722	COG0173 Aspartyl-tRNA synthetase.	COG2331 Uncharacterized protein conserved in bacteria.	0.674
EAR60127.1	EAR60128.1	MED92_08727	MED92_08732	COG0173 Aspartyl-tRNA synthetase.	Hypothetical protein.	0.886
EAR60127.1	EAR60131.1	MED92_08727	MED92_08747	COG0173 Aspartyl-tRNA synthetase.	COG0632 Holliday junction resolvasome, DNA-binding subunit.	0.814
EAR60127.1	ruvC	MED92_08727	MED92_08737	COG0173 Aspartyl-tRNA synthetase.	COG0817 Holliday junction resolvasome, endonuclease subunit.	0.782
EAR60128.1	EAR60126.1	MED92_08732	MED92_08722	Hypothetical protein.	COG2331 Uncharacterized protein conserved in bacteria.	0.454
EAR60128.1	EAR60127.1	MED92_08732	MED92_08727	Hypothetical protein.	COG0173 Aspartyl-tRNA synthetase.	0.886
EAR60128.1	EAR60131.1	MED92_08732	MED92_08747	Hypothetical protein.	COG0632 Holliday junction resolvasome, DNA-binding subunit.	0.832
EAR60128.1	ruvC	MED92_08732	MED92_08737	Hypothetical protein.	COG0817 Holliday junction resolvasome, endonuclease subunit.	0.816
EAR60131.1	EAR60126.1	MED92_08747	MED92_08722	COG0632 Holliday junction resolvasome, DNA-binding subunit.	COG2331 Uncharacterized protein conserved in bacteria.	0.421
EAR60131.1	EAR60127.1	MED92_08747	MED92_08727	COG0632 Holliday junction resolvasome, DNA-binding subunit.	COG0173 Aspartyl-tRNA synthetase.	0.814
EAR60131.1	EAR60128.1	MED92_08747	MED92_08732	COG0632 Holliday junction resolvasome, DNA-binding subunit.	Hypothetical protein.	0.832

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Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.929

expected number of edges:

15

PPI enrichment p-value:

8.4e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010467

Gene expression

10 of 1088

0.97

1.05

2.90e-06

GO:0006473

Protein acetylation

3 of 43

1.85

1.02

0.0102

GO:0006474

N-terminal protein amino acid acetylation

2 of 9

2.35

1.02

0.0135

GO:0051604

Protein maturation

3 of 88

1.54

0.81

0.0209

GO:0006412

Translation

5 of 298

1.23

0.8

0.0102

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

5 of 164

1.49

1.36

0.00051

GO:0004596

Peptide alpha-N-acetyltransferase activity

2 of 8

2.4

0.92

0.0208

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031415

NatA complex

3 of 3

3.01

2.89

5.31e-06

GO:0022625

Cytosolic large ribosomal subunit

5 of 48

2.02

2.87

7.47e-07

GO:1990904

Ribonucleoprotein complex

6 of 444

1.14

1.11

0.00017

GO:0032991

Protein-containing complex

9 of 1815

0.7

0.6

0.00030

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18270

N-terminal protein acetyltransferase complex, and peptide-serine-N-acetyltransferase activity

4 of 8

2.71

3.39

4.87e-07

CL:7014

Cytosolic large ribosomal subunit

4 of 31

2.12

2.48

1.02e-05

CL:7016

Cytosolic large ribosomal subunit

3 of 14

2.34

2.11

9.74e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

5 of 183

1.44

1.54

8.35e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

5 of 117

1.64

1.79

5.91e-05

MAP-975956

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

5 of 124

1.61

1.76

5.91e-05

MAP-72689

Formation of a pool of free 40S subunits

5 of 125

1.61

1.76

5.91e-05

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

5 of 127

1.6

1.75

5.91e-05

MAP-975957

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

5 of 135

1.57

1.72

5.91e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031415

NatA complex

3 of 4

2.88

2.52

2.45e-05

GOCC:0022625

Cytosolic large ribosomal subunit

4 of 43

1.97

2.11

4.39e-05

GOCC:1990904

Ribonucleoprotein complex

5 of 438

1.06

0.81

0.0036

GOCC:0032991

Protein-containing complex

8 of 2389

0.53

0.34

0.0340

GOCC:0005737

Cytoplasm

9 of 3329

0.44

0.29

0.0423

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