EAR60647.1 protein (Neptuniibacter caesariensis)

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

EAR60647.1

COG1806 Uncharacterized protein conserved in bacteria. (272 aa)

Predicted Functional Partners:

EAR60648.1

0.963

EAR60646.1

0.668

EAR61065.1

0.663

EAR62767.1

0.653

EAR60255.1

0.588

EAR60582.1

0.588

glyS

0.449

Your Current Organism:

Neptuniibacter caesariensis

NCBI taxonomy Id: 207954
Other names: CCUG 52065, CECT 7075, N. caesariensis, Neptuniibacter caesariensis Arahal et al. 2007, Oceanospirillum sp. MED92, strain MED92

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAR60255.1	EAR60647.1	MED92_02279	MED92_09591	Hypothetical protein; COG0517 FOG: CBS domain.	COG1806 Uncharacterized protein conserved in bacteria.	0.588
EAR60582.1	EAR60647.1	MED92_17000	MED92_09591	COG2905 Predicted signal-transduction protein containing cAMP-binding and CBS domains.	COG1806 Uncharacterized protein conserved in bacteria.	0.588
EAR60646.1	EAR60647.1	MED92_09586	MED92_09591	COG4254 Uncharacterized protein conserved in bacteria.	COG1806 Uncharacterized protein conserved in bacteria.	0.668
EAR60647.1	EAR60255.1	MED92_09591	MED92_02279	COG1806 Uncharacterized protein conserved in bacteria.	Hypothetical protein; COG0517 FOG: CBS domain.	0.588
EAR60647.1	EAR60582.1	MED92_09591	MED92_17000	COG1806 Uncharacterized protein conserved in bacteria.	COG2905 Predicted signal-transduction protein containing cAMP-binding and CBS domains.	0.588
EAR60647.1	EAR60646.1	MED92_09591	MED92_09586	COG1806 Uncharacterized protein conserved in bacteria.	COG4254 Uncharacterized protein conserved in bacteria.	0.668
EAR60647.1	EAR60648.1	MED92_09591	MED92_09596	COG1806 Uncharacterized protein conserved in bacteria.	COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase.	0.963
EAR60647.1	EAR61065.1	MED92_09591	MED92_01609	COG1806 Uncharacterized protein conserved in bacteria.	Hypothetical protein; COG0794 Predicted sugar phosphate isomerase involved in capsule formation.	0.663
EAR60647.1	EAR62767.1	MED92_09591	MED92_06598	COG1806 Uncharacterized protein conserved in bacteria.	Sensory box/GGDEF/EAL/CBS domain protein; COG2202 FOG: PAS/PAC domain.	0.653
EAR60647.1	glyS	MED92_09591	MED92_05713	COG1806 Uncharacterized protein conserved in bacteria.	COG0751 Glycyl-tRNA synthetase, beta subunit.	0.449
EAR60648.1	EAR60647.1	MED92_09596	MED92_09591	COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase.	COG1806 Uncharacterized protein conserved in bacteria.	0.963
EAR60648.1	EAR61065.1	MED92_09596	MED92_01609	COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase.	Hypothetical protein; COG0794 Predicted sugar phosphate isomerase involved in capsule formation.	0.501
EAR60648.1	EAR62767.1	MED92_09596	MED92_06598	COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase.	Sensory box/GGDEF/EAL/CBS domain protein; COG2202 FOG: PAS/PAC domain.	0.401
EAR61065.1	EAR60647.1	MED92_01609	MED92_09591	Hypothetical protein; COG0794 Predicted sugar phosphate isomerase involved in capsule formation.	COG1806 Uncharacterized protein conserved in bacteria.	0.663
EAR61065.1	EAR60648.1	MED92_01609	MED92_09596	Hypothetical protein; COG0794 Predicted sugar phosphate isomerase involved in capsule formation.	COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase.	0.501
EAR62767.1	EAR60647.1	MED92_06598	MED92_09591	Sensory box/GGDEF/EAL/CBS domain protein; COG2202 FOG: PAS/PAC domain.	COG1806 Uncharacterized protein conserved in bacteria.	0.653
EAR62767.1	EAR60648.1	MED92_06598	MED92_09596	Sensory box/GGDEF/EAL/CBS domain protein; COG2202 FOG: PAS/PAC domain.	COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase.	0.401
glyS	EAR60647.1	MED92_05713	MED92_09591	COG0751 Glycyl-tRNA synthetase, beta subunit.	COG1806 Uncharacterized protein conserved in bacteria.	0.449

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.934

expected number of edges:

41

PPI enrichment p-value:

0.489

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009168

Purine ribonucleoside monophosphate biosynthetic process

10 of 27

2.02

5.92

1.38e-16

GO:0006189

De novo IMP biosynthetic process

8 of 19

2.08

5.41

6.46e-14

GO:0009152

Purine ribonucleotide biosynthetic process

10 of 43

1.82

4.8

9.62e-16

GO:0006167

AMP biosynthetic process

3 of 5

2.23

2.32

3.04e-05

GO:0044208

De novo AMP biosynthetic process

2 of 2

2.45

1.6

0.0011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

7 of 41

1.69

2.84

1.81e-08

GO:0004642

Phosphoribosylformylglycinamidine synthase activity

3 of 3

2.45

2.19

7.71e-05

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

2 of 4

2.15

1.29

0.0036

GO:0043168

Anion binding

8 of 274

0.92

0.87

7.71e-05

GO:0035639

Purine ribonucleoside triphosphate binding

7 of 231

0.93

0.85

0.00022

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 711

0.64

0.59

1.14e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1000

IMP metabolic process

7 of 13

2.18

5.07

5.11e-12

CL:997

Ribonucleoside monophosphate biosynthetic process

9 of 31

1.92

4.84

5.51e-14

CL:996

Ribonucleoside monophosphate biosynthetic process, and One-carbon metabolic process

10 of 41

1.84

4.79

3.32e-15

CL:1002

Phosphoribosylformylglycinamidine synthase activity, and Formyl transferase

5 of 6

2.37

4.13

5.55e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

nvn00230

Purine metabolism

10 of 52

1.74

4.31

4.03e-15

nvn01110

Biosynthesis of secondary metabolites

9 of 172

1.17

1.62

8.42e-09

nvn00250

Alanine, aspartate and glutamate metabolism

3 of 27

1.5

1.13

0.0027

nvn00670

One carbon pool by folate

2 of 7

1.91

1.11

0.0068

nvn01100

Metabolic pathways

11 of 394

0.9

1.04

6.41e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

10 of 471

0.78

0.74

1.47e-05

GOCC:0005622

Intracellular

11 of 790

0.6

0.53

3.34e-05

GOCC:0110165

Cellular anatomical entity

11 of 1017

0.49

0.41

0.00035

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

7 of 14

2.15

4.9

1.00e-11

KW-0436

Ligase

7 of 76

1.42

2.05

1.66e-07

KW-0963

Cytoplasm

7 of 94

1.33

1.79

4.50e-07

KW-0547

Nucleotide-binding

7 of 136

1.16

1.36

3.91e-06

KW-0067

ATP-binding

6 of 121

1.15

1.2

4.78e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02769

AIR synthase related protein, C-terminal domain

2 of 3

2.28

0.8

0.0346

PF00586

AIR synthase related protein, N-terminal domain

2 of 3

2.28

0.8

0.0346

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