EAR60759.1 protein (Neptuniibacter caesariensis)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

EAR60759.1

Chemotaxis response regulator; COG0784 FOG: CheY-like receiver. (120 aa)

Predicted Functional Partners:

EAR62000.1

0.997

EAR59994.1

0.995

EAR61283.1

0.991

EAR62342.1

0.987

EAR61545.1

0.985

EAR62120.1

0.984

EAR60243.1

0.984

EAR61560.1

0.983

EAR60758.1

0.980

EAR60585.1

0.979

Your Current Organism:

Neptuniibacter caesariensis

NCBI taxonomy Id: 207954
Other names: CCUG 52065, CECT 7075, N. caesariensis, Neptuniibacter caesariensis Arahal et al. 2007, Oceanospirillum sp. MED92, strain MED92

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAR59994.1	EAR60243.1	MED92_14033	MED92_17389	Serine/threonine kinase with two-component sensor domain; COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.999
EAR59994.1	EAR60585.1	MED92_14033	MED92_17015	Serine/threonine kinase with two-component sensor domain; COG0642 Signal transduction histidine kinase.	Two-component system sensor protein; COG0591 Na+/proline symporter.	0.999
EAR59994.1	EAR60758.1	MED92_14033	MED92_13823	Serine/threonine kinase with two-component sensor domain; COG0642 Signal transduction histidine kinase.	CheA signal transduction histidine kinase; COG0643 Chemotaxis protein histidine kinase and related kinases.	0.986
EAR59994.1	EAR60759.1	MED92_14033	MED92_13828	Serine/threonine kinase with two-component sensor domain; COG0642 Signal transduction histidine kinase.	Chemotaxis response regulator; COG0784 FOG: CheY-like receiver.	0.995
EAR59994.1	EAR61283.1	MED92_14033	MED92_11169	Serine/threonine kinase with two-component sensor domain; COG0642 Signal transduction histidine kinase.	Histidine kinase response regulator hybrid protein; COG2203 FOG: GAF domain.	0.999
EAR59994.1	EAR61545.1	MED92_14033	MED92_12861	Serine/threonine kinase with two-component sensor domain; COG0642 Signal transduction histidine kinase.	COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain.	0.999
EAR59994.1	EAR61560.1	MED92_14033	MED92_12936	Serine/threonine kinase with two-component sensor domain; COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.999
EAR59994.1	EAR62000.1	MED92_14033	MED92_09854	Serine/threonine kinase with two-component sensor domain; COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.999
EAR59994.1	EAR62120.1	MED92_14033	MED92_10454	Serine/threonine kinase with two-component sensor domain; COG0642 Signal transduction histidine kinase.	Sensory box histidine kinase/response regulator; COG2202 FOG: PAS/PAC domain.	0.999
EAR59994.1	EAR62342.1	MED92_14033	MED92_14933	Serine/threonine kinase with two-component sensor domain; COG0642 Signal transduction histidine kinase.	Serine/threonine kinase with two-component sensor domain; COG3899 Predicted ATPase.	0.999
EAR60243.1	EAR59994.1	MED92_17389	MED92_14033	COG0642 Signal transduction histidine kinase.	Serine/threonine kinase with two-component sensor domain; COG0642 Signal transduction histidine kinase.	0.999
EAR60243.1	EAR60585.1	MED92_17389	MED92_17015	COG0642 Signal transduction histidine kinase.	Two-component system sensor protein; COG0591 Na+/proline symporter.	0.999
EAR60243.1	EAR60758.1	MED92_17389	MED92_13823	COG0642 Signal transduction histidine kinase.	CheA signal transduction histidine kinase; COG0643 Chemotaxis protein histidine kinase and related kinases.	0.916
EAR60243.1	EAR60759.1	MED92_17389	MED92_13828	COG0642 Signal transduction histidine kinase.	Chemotaxis response regulator; COG0784 FOG: CheY-like receiver.	0.984
EAR60243.1	EAR61283.1	MED92_17389	MED92_11169	COG0642 Signal transduction histidine kinase.	Histidine kinase response regulator hybrid protein; COG2203 FOG: GAF domain.	0.999
EAR60243.1	EAR61545.1	MED92_17389	MED92_12861	COG0642 Signal transduction histidine kinase.	COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain.	0.999
EAR60243.1	EAR61560.1	MED92_17389	MED92_12936	COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.999
EAR60243.1	EAR62000.1	MED92_17389	MED92_09854	COG0642 Signal transduction histidine kinase.	COG0642 Signal transduction histidine kinase.	0.999
EAR60243.1	EAR62120.1	MED92_17389	MED92_10454	COG0642 Signal transduction histidine kinase.	Sensory box histidine kinase/response regulator; COG2202 FOG: PAS/PAC domain.	0.999
EAR60243.1	EAR62342.1	MED92_17389	MED92_14933	COG0642 Signal transduction histidine kinase.	Serine/threonine kinase with two-component sensor domain; COG3899 Predicted ATPase.	0.999

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Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.958

expected number of edges:

27

PPI enrichment p-value:

1.2e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009165

Nucleotide biosynthetic process

4 of 100

1.39

0.92

0.0076

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

3 of 10

2.26

1.53

0.0013

GO:0003824

Catalytic activity

11 of 2198

0.49

0.39

0.0021

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005753

Mitochondrial proton-transporting ATP synthase complex

3 of 13

2.15

1.49

0.0014

GO:0005754

Mitochondrial proton-transporting ATP synthase, catalytic core

2 of 2

2.79

1.33

0.0039

GO:0005743

Mitochondrial inner membrane

4 of 211

1.06

0.63

0.0230

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8553

Proton-transporting ATP synthase complex

3 of 11

2.22

1.68

0.00064

CL:7856

Mixed, incl. Cellular ketone metabolic process, and Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

4 of 41

1.78

1.53

0.00061

CL:7859

Mixed, incl. Tryptophan catabolic process, and Flavin monooxygenase-like

3 of 18

2.01

1.49

0.0012

CL:8556

Proton-transporting ATP synthase complex, catalytic core F(1)

2 of 6

2.31

1.1

0.0093

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-211945

Phase I - Functionalization of compounds

3 of 37

1.7

0.79

0.0275

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

3 of 13

2.15

1.47

0.0016

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

2 of 5

2.39

0.99

0.0150

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0139

CF(1)

2 of 3

2.61

1.24

0.0055

KW-0066

ATP synthesis

2 of 3

2.61

1.24

0.0055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07859

Alpha/beta hydrolase fold

2 of 2

2.79

1.08

0.0110

PF02874

ATP synthase alpha/beta family, beta-barrel domain

2 of 4

2.49

1.02

0.0137

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