STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (494 aa)    
Predicted Functional Partners:
trpC
COG0134 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 0.999
EAR60866.1
Glutamine amidotransferase of anthranilate synthase; COG0512 Anthranilate/para-aminobenzoate synthases component II.
 0.999
EAR59881.1
Glycosyl transferase, family 3; COG0547 Anthranilate phosphoribosyltransferase.
 
 0.984
EAR61760.1
COG0135 Phosphoribosylanthranilate isomerase.
 
 
 0.970
EAR60808.1
Chorismate mutase, gamma, beta and epsilon proteobacteria; COG1605 Chorismate mutase.
 
 
 0.966
EAR61736.1
COG0082 Chorismate synthase.
 
 
 0.950
EAR61762.1
COG0159 Tryptophan synthase alpha chain.
 
  
 0.946
EAR61815.1
COG0147 Anthranilate/para-aminobenzoate synthases component I.
  
  
 
0.918
ubiC
Hypothetical protein; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family.
    
 0.906
Your Current Organism:
Neptuniibacter caesariensis
NCBI taxonomy Id: 207954
Other names: CCUG 52065, CECT 7075, N. caesariensis, Neptuniibacter caesariensis Arahal et al. 2007, Oceanospirillum sp. MED92, strain MED92
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.