STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadENAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (276 aa)    
Predicted Functional Partners:
nadR
HTH-type transcriptional regulator, transcriptional repressor of NAD biosynthesis genes; Catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; catalyzes the formation of nicotinamide mononucleotide from nicotinamide riboside; also has a regulatory function; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.949
nadD
Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
 
 0.947
ppnK
NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
    
 0.930
cobB
NAD-dependent protein deacylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily.
    
 0.929
APZ04281.1
ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.920
APZ06383.1
NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
     
 0.911
nudC
NADH pyrophosphatase; Can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Nudix hydrolase family. NudC subfamily.
  
 
 0.907
sthA
NAD(P)(+) transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
    
 0.903
pntA
NAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family.
     
 0.902
APZ05401.1
Nucleoside triphosphate pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
  0.900
Your Current Organism:
Kosakonia cowanii
NCBI taxonomy Id: 208223
Other names: CCUG 45998 A, CCUG 45998 B, CIP 107300, DSM 18146, Enterobacter cowanii, Enterobacter cowanii Inoue et al. 2001, JCM 10956, K. cowanii, Kosakonia cowanii (Inoue et al. 2001) Brady et al. 2013, LMG 23569, LMG:23569, NIH group 42, strain 888-76, strain KSK 246, strain UM-79
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