| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SAG0092 | SAG0093 | SAG0092 | SAG0093 | Identified by match to PFAM protein family HMM PF00300. | Identified by match to PFAM protein family HMM PF02557. | 0.841 |
| SAG0092 | SAG0094 | SAG0092 | SAG0094 | Identified by match to PFAM protein family HMM PF00300. | N-acetylmuramoyl-L-alanine amidase, family 4 protein; Identified by match to PFAM protein family HMM PF01832. | 0.841 |
| SAG0092 | dnaK | SAG0092 | SAG0097 | Identified by match to PFAM protein family HMM PF00300. | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.496 |
| SAG0092 | grpE | SAG0092 | SAG0096 | Identified by match to PFAM protein family HMM PF00300. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.675 |
| SAG0092 | hrcA | SAG0092 | SAG0095 | Identified by match to PFAM protein family HMM PF00300. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.650 |
| SAG0093 | SAG0092 | SAG0093 | SAG0092 | Identified by match to PFAM protein family HMM PF02557. | Identified by match to PFAM protein family HMM PF00300. | 0.841 |
| SAG0093 | SAG0094 | SAG0093 | SAG0094 | Identified by match to PFAM protein family HMM PF02557. | N-acetylmuramoyl-L-alanine amidase, family 4 protein; Identified by match to PFAM protein family HMM PF01832. | 0.898 |
| SAG0093 | grpE | SAG0093 | SAG0096 | Identified by match to PFAM protein family HMM PF02557. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.643 |
| SAG0093 | hrcA | SAG0093 | SAG0095 | Identified by match to PFAM protein family HMM PF02557. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.692 |
| SAG0094 | SAG0092 | SAG0094 | SAG0092 | N-acetylmuramoyl-L-alanine amidase, family 4 protein; Identified by match to PFAM protein family HMM PF01832. | Identified by match to PFAM protein family HMM PF00300. | 0.841 |
| SAG0094 | SAG0093 | SAG0094 | SAG0093 | N-acetylmuramoyl-L-alanine amidase, family 4 protein; Identified by match to PFAM protein family HMM PF01832. | Identified by match to PFAM protein family HMM PF02557. | 0.898 |
| SAG0094 | dnaK | SAG0094 | SAG0097 | N-acetylmuramoyl-L-alanine amidase, family 4 protein; Identified by match to PFAM protein family HMM PF01832. | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.422 |
| SAG0094 | grpE | SAG0094 | SAG0096 | N-acetylmuramoyl-L-alanine amidase, family 4 protein; Identified by match to PFAM protein family HMM PF01832. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.650 |
| SAG0094 | hrcA | SAG0094 | SAG0095 | N-acetylmuramoyl-L-alanine amidase, family 4 protein; Identified by match to PFAM protein family HMM PF01832. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.650 |
| clpP | ctsR | SAG1585 | SAG1829 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Transcriptional regulator CtsR; Similar to GB:D26185 SP:P37568 PID:467471 GB:AL009126; identified by sequence similarity; putative; Belongs to the CtsR family. | 0.711 |
| clpP | dnaJ | SAG1585 | SAG0098 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.682 |
| clpP | dnaK | SAG1585 | SAG0097 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.827 |
| clpP | groEL | SAG1585 | SAG2074 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 60 kda chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.914 |
| clpP | groES | SAG1585 | SAG2075 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.907 |
| clpP | grpE | SAG1585 | SAG0096 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.854 |
