Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hitHIT family protein; Identified by match to PFAM protein family HMM PF01230. (139 aa)    
Predicted Functional Partners:
SAG0369
Conserved hypothetical protein; Identified by Glimmer2; putative.
       0.841
udk
Uridine kinase; Identified by match to PFAM protein family HMM PF00485.
   
  0.822
glnA
Glutamine synthetase, type I; Identified by match to PFAM protein family HMM PF00120; Belongs to the glutamine synthetase family.
   
   0.782
SAG1057
Conserved hypothetical protein; Identified by Glimmer2; putative.
    
  0.746
lysS
lysyl-tRNA synthetase; Identified by match to PFAM protein family HMM PF00152; Belongs to the class-II aminoacyl-tRNA synthetase family.
 
 
 0.741
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
 
 
  0.535
SAG0374
ABC transporter, permease protein; Similar to OMNI:NTL01SPL1360; identified by sequence similarity; putative.
     
 0.509
SAG1537
Identified by match to PFAM protein family HMM PF00293.
  
 0.506
SAG0487
Identified by match to PFAM protein family HMM PF00293.
  
 0.503
SAG0451
Bacteriocin transport accessory protein, putative.
  
  0.468
Your Current Organism:
Streptococcus agalactiae
NCBI taxonomy Id: 208435
Other names: S. agalactiae 2603V/R, Streptococcus agalactiae 2603V/R, Streptococcus agalactiae str. 2603V/R
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