STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
sdhBL-serine dehydratase, iron-sulfur-dependent, beta subunit; Identified by match to PFAM protein family HMM PF01842; Belongs to the iron-sulfur dependent L-serine dehydratase family. (222 aa)    
Predicted Functional Partners:
sdhA
L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Identified by match to PFAM protein family HMM PF03313; Belongs to the iron-sulfur dependent L-serine dehydratase family.
 
 0.999
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.958
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.925
serB
Phosphoserine phosphatase SerB; Identified by match to PFAM protein family HMM PF00702.
   
 
 0.914
cysE
Serine O-acetyltransferase; Identified by match to PFAM protein family HMM PF00132.
     
 0.911
hom
Homoserine dehydrogenase; Identified by match to PFAM protein family HMM PF00742.
   
 
  0.906
gloA
Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
    
  0.904
SAG1541
Glyoxalase family protein.
     
  0.817
SAG1806
Glyoxylate reductase, NADH-dependent; Identified by match to PFAM protein family HMM PF00389; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
 0.706
SAG0751
Hydrolase, haloacid dehalogenase-like family; Identified by match to PFAM protein family HMM PF00702.
    
  0.698
Your Current Organism:
Streptococcus agalactiae
NCBI taxonomy Id: 208435
Other names: S. agalactiae 2603V/R, Streptococcus agalactiae 2603V/R, Streptococcus agalactiae str. 2603V/R
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.