Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SAG2172ABC transporter, permease protein, putative; Similar to OMNI:NTL01SPL1730; identified by sequence similarity; putative. (859 aa)    
Predicted Functional Partners:
SAG1479
Glycosyl transferase, group 2 family protein; Identified by match to PFAM protein family HMM PF00535.
 
 
 0.913
dltC
D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
     
 0.730
dltD
dltD protein; Similar to OMNI:SP2173; identified by sequence similarity; putative.
  
 
  0.702
SAG1381
Sulfatase; Identified by match to PFAM protein family HMM PF00884.
    
  0.700
dltB
dltB protein; Could be involved in the transport of activated D-alanine through the membrane.
     
  0.696
dltA
D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...]
     
  0.696
SAG2171
ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005.
       0.662
SAG1072
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
     0.657
SAG0162
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
     0.647
SAG1099
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
     0.644
Your Current Organism:
Streptococcus agalactiae
NCBI taxonomy Id: 208435
Other names: S. agalactiae 2603V/R, Streptococcus agalactiae 2603V/R, Streptococcus agalactiae str. 2603V/R
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