STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SED53946.1Pyrroloquinoline quinone biosynthesis protein D. (88 aa)    
Predicted Functional Partners:
pqqB
Pyrroloquinoline quinone biosynthesis protein B; May be involved in the transport of PQQ or its precursor to the periplasm; Belongs to the PqqB family.
 
  
 0.967
pqqC
Pyrroloquinoline-quinone synthase; Ring cyclization and eight-electron oxidation of 3a-(2-amino- 2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9- dicarboxylic-acid to PQQ.
 
  
 0.964
pqqE
Pyrroloquinoline quinone biosynthesis protein E; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
 
     0.955
SED71838.1
Molybdenum cofactor synthesis domain-containing protein.
  
 
 0.761
ribBA
3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
    
  0.716
SEC40319.1
Ribonucleoside-diphosphate reductase class II; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
    
  0.670
SED54023.1
Helix-turn-helix domain-containing protein.
       0.631
SED54050.1
Predicted arabinose efflux permease, MFS family.
       0.631
SED08095.1
Hypothetical protein.
  
     0.613
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.577
Your Current Organism:
Amycolatopsis tolypomycina
NCBI taxonomy Id: 208445
Other names: A. tolypomycina, ATCC 21177, Amycolatopsis tolypomycina Wink et al. 2003, Amycolatopsis tolypophora, Amycolatopsis tolypophorous, DSM 44544, IFO 14664, IMSNU 20061, JCM 4936, NBRC 14664, NRRL B-24205, Streptomyces tolypophorus
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