node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEA37879.1 | SEA40396.1 | SAMN02910418_01464 | SAMN02910418_01532 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | phosphoribosyl-AMP cyclohydrolase. | 0.998 |
SEA37879.1 | SEA44396.1 | SAMN02910418_01464 | SAMN02910418_01606 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | Histidinol-phosphate aminotransferase. | 0.885 |
SEA37879.1 | hisA | SAMN02910418_01464 | SAMN02910418_01602 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.993 |
SEA37879.1 | hisB | SAMN02910418_01464 | SAMN02910418_01605 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | Imidazoleglycerol-phosphate dehydratase. | 0.993 |
SEA37879.1 | hisC | SAMN02910418_01464 | SAMN02910418_00777 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.754 |
SEA37879.1 | hisD | SAMN02910418_01464 | SAMN02910418_01608 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.989 |
SEA37879.1 | hisF | SAMN02910418_01464 | SAMN02910418_01533 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.991 |
SEA37879.1 | hisG | SAMN02910418_01464 | SAMN02910418_01463 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
SEA37879.1 | hisH | SAMN02910418_01464 | SAMN02910418_01603 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.970 |
SEA37879.1 | purH | SAMN02910418_01464 | SAMN02910418_01020 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.469 |
SEA40396.1 | SEA37879.1 | SAMN02910418_01532 | SAMN02910418_01464 | phosphoribosyl-AMP cyclohydrolase. | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | 0.998 |
SEA40396.1 | SEA44396.1 | SAMN02910418_01532 | SAMN02910418_01606 | phosphoribosyl-AMP cyclohydrolase. | Histidinol-phosphate aminotransferase. | 0.907 |
SEA40396.1 | hisA | SAMN02910418_01532 | SAMN02910418_01602 | phosphoribosyl-AMP cyclohydrolase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.999 |
SEA40396.1 | hisB | SAMN02910418_01532 | SAMN02910418_01605 | phosphoribosyl-AMP cyclohydrolase. | Imidazoleglycerol-phosphate dehydratase. | 0.996 |
SEA40396.1 | hisC | SAMN02910418_01532 | SAMN02910418_00777 | phosphoribosyl-AMP cyclohydrolase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.847 |
SEA40396.1 | hisD | SAMN02910418_01532 | SAMN02910418_01608 | phosphoribosyl-AMP cyclohydrolase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.995 |
SEA40396.1 | hisF | SAMN02910418_01532 | SAMN02910418_01533 | phosphoribosyl-AMP cyclohydrolase. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
SEA40396.1 | hisG | SAMN02910418_01532 | SAMN02910418_01463 | phosphoribosyl-AMP cyclohydrolase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.994 |
SEA40396.1 | hisH | SAMN02910418_01532 | SAMN02910418_01603 | phosphoribosyl-AMP cyclohydrolase. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.994 |
SEA40396.1 | purH | SAMN02910418_01532 | SAMN02910418_01020 | phosphoribosyl-AMP cyclohydrolase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.479 |