STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SEA65505.1Subtilase family protein. (1226 aa)    
Predicted Functional Partners:
SEA69125.1
Hypothetical protein.
 
 0.789
SEA72561.1
DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family.
  
 
 0.536
secY
Protein translocase subunit secY/sec61 alpha; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
    
   0.508
SEA70832.1
Cytochrome oxidase assembly protein ShyY1.
    
   0.508
SEA65528.1
Hypothetical protein.
       0.458
proS
prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...]
       0.452
SEA65583.1
Protein of unknown function, DUF488.
       0.452
SEA77665.1
DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family.
  
   0.442
rplP
Large subunit ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.
   
   0.435
SEA14322.1
DNA-binding transcriptional regulator, MerR family.
  
     0.411
Your Current Organism:
Actinomyces nasicola
NCBI taxonomy Id: 208480
Other names: A. nasicola, Actinomyces nasico, Actinomyces nasicola Hall et al. 2003, CCUG 46092, CIP 107668, DSM 19116, strain R2014
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.