| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| adhE | birA | CAR_c06980 | CAR_c02360 | Bifunctional enzyme: alcohol dehydrogenase, acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.489 |
| adhE | kdgK2 | CAR_c06980 | CAR_c20920 | Bifunctional enzyme: alcohol dehydrogenase, acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 2-dehydro-3-deoxygluconokinase. | 0.513 |
| adhE | ldh1 | CAR_c06980 | CAR_c01880 | Bifunctional enzyme: alcohol dehydrogenase, acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.544 |
| adhE | ldh2 | CAR_c06980 | CAR_c09220 | Bifunctional enzyme: alcohol dehydrogenase, acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. | 0.544 |
| adhE | mgsA | CAR_c06980 | CAR_c02670 | Bifunctional enzyme: alcohol dehydrogenase, acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. | 0.418 |
| adhE | pyk | CAR_c06980 | CAR_c10110 | Bifunctional enzyme: alcohol dehydrogenase, acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.625 |
| birA | adhE | CAR_c02360 | CAR_c06980 | Biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Bifunctional enzyme: alcohol dehydrogenase, acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.489 |
| birA | cca | CAR_c02360 | CAR_c10370 | Biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | tRNA CCA-pyrophosphorylase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | 0.864 |
| birA | dapB | CAR_c02360 | CAR_c10360 | Biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.756 |
| birA | mgsA | CAR_c02360 | CAR_c02670 | Biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. | 0.786 |
| cca | birA | CAR_c10370 | CAR_c02360 | tRNA CCA-pyrophosphorylase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | Biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.864 |
| cca | dapB | CAR_c10370 | CAR_c10360 | tRNA CCA-pyrophosphorylase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.961 |
| cca | mgsA | CAR_c10370 | CAR_c02670 | tRNA CCA-pyrophosphorylase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. | 0.854 |
| coaE | mgsA | CAR_c07310 | CAR_c02670 | Dephosphocoenzyme A kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. | 0.879 |
| dapB | birA | CAR_c10360 | CAR_c02360 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | Biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.756 |
| dapB | cca | CAR_c10360 | CAR_c10370 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | tRNA CCA-pyrophosphorylase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | 0.961 |
| dapB | mgsA | CAR_c10360 | CAR_c02670 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. | 0.771 |
| kdgK2 | adhE | CAR_c20920 | CAR_c06980 | 2-dehydro-3-deoxygluconokinase. | Bifunctional enzyme: alcohol dehydrogenase, acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.513 |
| kdgK2 | mgsA | CAR_c20920 | CAR_c02670 | 2-dehydro-3-deoxygluconokinase. | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. | 0.556 |
| kdgK2 | pyk | CAR_c20920 | CAR_c10110 | 2-dehydro-3-deoxygluconokinase. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.557 |