STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mtlZFructokinase; Product name confidence: Class 2 (High similarity to functionally studied protein). (310 aa)    
Predicted Functional Partners:
mtlD
Mannitol dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the mannitol dehydrogenase family.
 
  
 0.985
fruA
Phosphotransferase system transporter fructose-specific IIBC component, FruA; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
     
 0.946
pgi
Glucose-6-phosphate isomerase; Product name confidence: Class 2 (High similarity to functionally studied protein).
  
 
 0.946
mtlR
Transcriptional regulator MtlR; Product name confidence: Class 2 (High similarity to functionally studied protein).
 
   
 0.933
PA3759
Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
  
 
 0.928
pslB
PslB; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa; Belongs to the mannose-6-phosphate isomerase type 2 family.
    
 0.920
algA
Phosphomannose isomerase / guanosine 5'-diphospho-D-mannose pyrophosphorylase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics; Belongs to the mannose-6-phosphate isomerase type 2 family.
    
 0.920
wbpW
Phosphomannose isomerase/GDP-mannose WbpW; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the mannose-6-phosphate isomerase type 2 family.
    
 0.920
glmS
Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
   
 0.914
fbp
Fructose-1,6-bisphosphatase; Product name confidence: Class 2 (High similarity to functionally studied protein).
     
 0.908
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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