node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA0935 | cpdA | PA0935 | PA4969 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Cyclic AMP (cAMP) Phosphodiesterase, CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.923 |
PA0935 | cyaA | PA0935 | PA5272 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.900 |
PA0935 | cyaB | PA0935 | PA3217 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.901 |
PA0935 | ndk | PA0935 | PA3807 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. The 12-kDa membrane-associated form synthesizes GTP in preference to other nucleoside triphosphates. Important for alginate synthesis; Belongs to the NDK family. | 0.900 |
PA0935 | nrdD | PA0935 | PA1920 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Class III (anaerobic) ribonucleoside-triphosphate reductase subunit, NrdD; Class 2: Function of highly similar gene experimentally demonstrated in another organism (and gene context consistent in terms of pathways its involved in (if known). | 0.900 |
PA0935 | pykA | PA0935 | PA4329 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Pyruvate kinase II; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the pyruvate kinase family. | 0.903 |
PA0935 | pykF | PA0935 | PA1498 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Pyruvate kinase I; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the pyruvate kinase family. | 0.900 |
PA0935 | relA | PA0935 | PA0934 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.971 |
PA0935 | spoT | PA0935 | PA5338 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.921 |
cpdA | PA0935 | PA4969 | PA0935 | Cyclic AMP (cAMP) Phosphodiesterase, CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | 0.923 |
cpdA | cyaA | PA4969 | PA5272 | Cyclic AMP (cAMP) Phosphodiesterase, CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.994 |
cpdA | cyaB | PA4969 | PA3217 | Cyclic AMP (cAMP) Phosphodiesterase, CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.993 |
cpdA | vfr | PA4969 | PA0652 | Cyclic AMP (cAMP) Phosphodiesterase, CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | Transcriptional regulator Vfr; Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production. | 0.911 |
cyaA | PA0935 | PA5272 | PA0935 | Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | 0.900 |
cyaA | cpdA | PA5272 | PA4969 | Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Cyclic AMP (cAMP) Phosphodiesterase, CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.994 |
cyaA | cyaB | PA5272 | PA3217 | Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein). | CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.989 |
cyaA | ndk | PA5272 | PA3807 | Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. The 12-kDa membrane-associated form synthesizes GTP in preference to other nucleoside triphosphates. Important for alginate synthesis; Belongs to the NDK family. | 0.900 |
cyaA | nrdD | PA5272 | PA1920 | Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Class III (anaerobic) ribonucleoside-triphosphate reductase subunit, NrdD; Class 2: Function of highly similar gene experimentally demonstrated in another organism (and gene context consistent in terms of pathways its involved in (if known). | 0.900 |
cyaA | pykA | PA5272 | PA4329 | Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Pyruvate kinase II; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the pyruvate kinase family. | 0.903 |
cyaA | pykF | PA5272 | PA1498 | Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Pyruvate kinase I; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the pyruvate kinase family. | 0.909 |