Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
oprIOuter membrane lipoprotein OprI precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (83 aa)    
Predicted Functional Partners:
oprF
Major porin and structural outer membrane porin OprF precursor; Has porin activity, forming small water-filled channels. Also has a structural role in determining cell shape and ability to grow in low-osmolarity medium; Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
   
  
 0.962
oprL
Peptidoglycan associated lipoprotein OprL precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
   
  
 0.944
fliC
Flagellin type B; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
      
 0.853
toxA
Exotoxin A precursor; An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38.
      
 0.826
oprG
Outer membrane protein OprG precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
   
  
 0.809
popB
Translocator protein PopB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
      
 0.776
hupB
DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family.
   
  
 0.762
oprH
PhoP/Q and low Mg2+ inducible outer membrane protein H1 precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
   
  
 0.736
azu
Azurin precursor; Transfers electrons from cytochrome c551 to cytochrome oxidase.
   
    0.715
PA1053
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
   
  
 0.699
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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