STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hsdM-2COG0286 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]. (476 aa)    
Predicted Functional Partners:
hsdS
Hypothetical protein; COG0732 Restriction endonuclease S subunits [Defense mechanisms].
 
   0.914
hsdR
Type I restriction modification system endonuclease (R) subunit HsdR; Subunit R is required for both nuclease and ATPase activities, but not for modification.
  
 
 0.850
hsdS-2
Hypothetical protein; COG0732 Restriction endonuclease S subunits [Defense mechanisms].
 
   0.801
hsdR-2
COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].
  
 
 0.775
BAQ54226.1
Hypothetical protein.
  
 
 0.757
BAQ54227.1
Hypothetical protein; Pfam01420 Methylase_S Type I restriction modification DNA specificity domain, This domain is also known as the target recognition domain (TRD). Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity subunit ( [...]
  
   0.755
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
   
   0.539
Your Current Organism:
Mycoplasma arginini
NCBI taxonomy Id: 2094
Other names: ATCC 23838, CIP 71.23, IFO 14476, M. arginini, MRL M1240/68, Mycoplasma leonis, NBRC 14476, NCTC 10129, strain G230
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