node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AOD25586.1 | pepA | MHMDBK_00666 | MHMDBK_00034 | ATPase AAA; Identified by sequence similarity; putative. | Leucyl aminopeptidase; Identified by sequence similarity; putative; Belongs to the peptidase M17 family. | 0.459 |
AOD25586.1 | pepF-1 | MHMDBK_00666 | MHMDBK_00263 | ATPase AAA; Identified by sequence similarity; putative. | Identified by sequence similarity; putative. | 0.443 |
AOD25586.1 | pepF-2 | MHMDBK_00666 | MHMDBK_00270 | ATPase AAA; Identified by sequence similarity; putative. | Identified by sequence similarity; putative. | 0.443 |
glyA | gmk | MHMDBK_00191 | MHMDBK_00501 | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | 0.627 |
glyA | pdhD | MHMDBK_00191 | MHMDBK_00604 | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | 0.969 |
glyA | pepA | MHMDBK_00191 | MHMDBK_00034 | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Leucyl aminopeptidase; Identified by sequence similarity; putative; Belongs to the peptidase M17 family. | 0.830 |
glyA | tkt | MHMDBK_00191 | MHMDBK_00260 | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative transketolase transmembrane protein; Identified by sequence similarity; putative; Belongs to the transketolase family. | 0.433 |
gmk | glyA | MHMDBK_00501 | MHMDBK_00191 | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.627 |
gmk | pepA | MHMDBK_00501 | MHMDBK_00034 | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | Leucyl aminopeptidase; Identified by sequence similarity; putative; Belongs to the peptidase M17 family. | 0.623 |
ldh | pdhD | MHMDBK_00027 | MHMDBK_00604 | L-lactate dehydrogenase; Identified by sequence similarity; putative; Belongs to the LDH/MDH superfamily. | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | 0.741 |
ldh | pepA | MHMDBK_00027 | MHMDBK_00034 | L-lactate dehydrogenase; Identified by sequence similarity; putative; Belongs to the LDH/MDH superfamily. | Leucyl aminopeptidase; Identified by sequence similarity; putative; Belongs to the peptidase M17 family. | 0.452 |
ldh | tkt | MHMDBK_00027 | MHMDBK_00260 | L-lactate dehydrogenase; Identified by sequence similarity; putative; Belongs to the LDH/MDH superfamily. | Putative transketolase transmembrane protein; Identified by sequence similarity; putative; Belongs to the transketolase family. | 0.851 |
pdhD | glyA | MHMDBK_00604 | MHMDBK_00191 | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.969 |
pdhD | ldh | MHMDBK_00604 | MHMDBK_00027 | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | L-lactate dehydrogenase; Identified by sequence similarity; putative; Belongs to the LDH/MDH superfamily. | 0.741 |
pdhD | pepA | MHMDBK_00604 | MHMDBK_00034 | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | Leucyl aminopeptidase; Identified by sequence similarity; putative; Belongs to the peptidase M17 family. | 0.630 |
pdhD | pepP | MHMDBK_00604 | MHMDBK_00178 | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | Metallopeptidase M24 family protein; Identified by sequence similarity; putative. | 0.573 |
pdhD | tkt | MHMDBK_00604 | MHMDBK_00260 | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | Putative transketolase transmembrane protein; Identified by sequence similarity; putative; Belongs to the transketolase family. | 0.682 |
pepA | AOD25586.1 | MHMDBK_00034 | MHMDBK_00666 | Leucyl aminopeptidase; Identified by sequence similarity; putative; Belongs to the peptidase M17 family. | ATPase AAA; Identified by sequence similarity; putative. | 0.459 |
pepA | glyA | MHMDBK_00034 | MHMDBK_00191 | Leucyl aminopeptidase; Identified by sequence similarity; putative; Belongs to the peptidase M17 family. | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.830 |
pepA | gmk | MHMDBK_00034 | MHMDBK_00501 | Leucyl aminopeptidase; Identified by sequence similarity; putative; Belongs to the peptidase M17 family. | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | 0.623 |