node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AOD25023.1 | AOD25304.1 | MHMDBK_00008 | MHMDBK_00353 | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | Glycine cleavage system H protein; Identified by sequence similarity; putative. | 0.973 |
AOD25023.1 | glyA | MHMDBK_00008 | MHMDBK_00191 | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.925 |
AOD25023.1 | metG | MHMDBK_00008 | MHMDBK_00295 | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | methionyl-tRNA synthetase; Identified by sequence similarity; putative. | 0.526 |
AOD25023.1 | pdhD | MHMDBK_00008 | MHMDBK_00604 | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | 0.997 |
AOD25071.1 | dhfR | MHMDBK_00076 | MHMDBK_00842 | Dihydrofolate reductase; Identified by sequence similarity; putative; Belongs to the dihydrofolate reductase family. | Dihydrofolate reductase; Identified by sequence similarity; putative; Belongs to the dihydrofolate reductase family. | 0.904 |
AOD25071.1 | glyA | MHMDBK_00076 | MHMDBK_00191 | Dihydrofolate reductase; Identified by sequence similarity; putative; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.920 |
AOD25071.1 | thyA | MHMDBK_00076 | MHMDBK_00794 | Dihydrofolate reductase; Identified by sequence similarity; putative; Belongs to the dihydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.960 |
AOD25304.1 | AOD25023.1 | MHMDBK_00353 | MHMDBK_00008 | Glycine cleavage system H protein; Identified by sequence similarity; putative. | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | 0.973 |
AOD25304.1 | glyA | MHMDBK_00353 | MHMDBK_00191 | Glycine cleavage system H protein; Identified by sequence similarity; putative. | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.959 |
AOD25304.1 | pdhD | MHMDBK_00353 | MHMDBK_00604 | Glycine cleavage system H protein; Identified by sequence similarity; putative. | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | 0.991 |
dhfR | AOD25071.1 | MHMDBK_00842 | MHMDBK_00076 | Dihydrofolate reductase; Identified by sequence similarity; putative; Belongs to the dihydrofolate reductase family. | Dihydrofolate reductase; Identified by sequence similarity; putative; Belongs to the dihydrofolate reductase family. | 0.904 |
dhfR | glyA | MHMDBK_00842 | MHMDBK_00191 | Dihydrofolate reductase; Identified by sequence similarity; putative; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.920 |
dhfR | thyA | MHMDBK_00842 | MHMDBK_00794 | Dihydrofolate reductase; Identified by sequence similarity; putative; Belongs to the dihydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.990 |
glyA | AOD25023.1 | MHMDBK_00191 | MHMDBK_00008 | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | 0.925 |
glyA | AOD25071.1 | MHMDBK_00191 | MHMDBK_00076 | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Dihydrofolate reductase; Identified by sequence similarity; putative; Belongs to the dihydrofolate reductase family. | 0.920 |
glyA | AOD25304.1 | MHMDBK_00191 | MHMDBK_00353 | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glycine cleavage system H protein; Identified by sequence similarity; putative. | 0.959 |
glyA | dhfR | MHMDBK_00191 | MHMDBK_00842 | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Dihydrofolate reductase; Identified by sequence similarity; putative; Belongs to the dihydrofolate reductase family. | 0.920 |
glyA | metG | MHMDBK_00191 | MHMDBK_00295 | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | methionyl-tRNA synthetase; Identified by sequence similarity; putative. | 0.683 |
glyA | pdhD | MHMDBK_00191 | MHMDBK_00604 | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. | 0.969 |
glyA | pepA | MHMDBK_00191 | MHMDBK_00034 | Serine hydroxymethyltransferase 3; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Leucyl aminopeptidase; Identified by sequence similarity; putative; Belongs to the peptidase M17 family. | 0.830 |