STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
srtAPutative sortase; Best Blastp Hit: gb|AAA73122.1| (M77279) alpha-amylase [unidentified cloning vector]. (246 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
 0.935
wapA
Best Blastp Hit: sp|P11000|WAPA_STRMU WALL-ASSOCIATED PROTEIN PRECURSOR >gi|98001|pir||S06992 wall-associated protein A precursor - Streptococcus mutans >gi|153858|gb|AAA88608.1| (M37842) wall-associated protein [Streptococcus mutans].
 
  
 0.853
secA
Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family.
   
  
 0.809
spaP
Cell surface antigen SpaP; Surface protein antigen implicated in dental caries; Belongs to the SpaP/Ssp5/SpaA family.
      
 0.759
dltB
Integral membrane protein possibly involved in D-alanine export; Could be involved in the transport of activated D-alanine through the membrane.
  
   
 0.739
yidC2
Putative inner membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity). Partially complements an E.coli yidC depletion experiment.
 
   
 0.725
yidC1
Conserved hypothetical protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity). Partially complements an E.coli yidC depletion experiment.
 
   
 0.725
gbpC
Glucan-binding protein C, GbpC; Best Blastp Hit: dbj|BAA12713.1| (D85031) glucan-binding protein C [Streptococcus mutans].
   
  
 0.661
gtfD
glucosyltransferase-S; Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris; Belongs to the glycosyl hydrolase 70 family.
   
  
 0.649
wapE
Hypothetical protein; Best Blastp Hit: gi|6324372 anchorage subunit of a-agglutinin; Aga1p [Saccharomyces cerevisiae] >gi|416592|sp|P32323|AGA1_YEAST A-AGGLUTININ ATTACHMENT SUBUNIT PRECURSOR >gi|101170|pir||A41258 a-agglutinin core protein AGA1 - yeast (Saccharomyces cerevisiae) >gi|170964|gb|AAA34382.1| (M60590) a-agglutinin core subunit [Saccharomyces cerevisiae] >gi|1302552|emb|CAA96325.1| (Z71659) ORF YNR044w [Saccharomyces cerevisiae].
   
  
 0.648
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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