STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vacBPutative exoribonuclease R (RNAase R); 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (778 aa)    
Predicted Functional Partners:
rny
Conserved hypothetical protein; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family.
     
 0.934
smpB
Putative SsrA-binding protein-like protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The rib [...]
  
  
 0.854
SMU_1634c
Conserved hypothetical protein; Best Blastp Hit: dbj|BAB05243.1| (AP001512) unknown conserved protein [Bacillus halodurans].
   
 0.745
SMU_561c
Putative hydrolase (MutT family); Best Blastp Hit: dbj|BAA33629.1| (AB012957) unknown [Vibrio cholerae].
   
 0.745
pnpA
Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
   
  
 0.742
rpsO
30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
   
 
 0.683
rs1
Best Blastp Hit: sp|P50889|RS1_LEULA 40S RIBOSOMAL PROTEIN S1 >gi|1565296|gb|AAB08978.1| (U24086) ribosomal protein S1 homolog; sequence specific DNA-binding protein [Leuconostoc lactis].
   
 
 0.604
SMU_1609c
Putative membrane protein involved in protein secretion, SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family.
  
  
 0.574
coaE
Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
  
  
 0.565
rsmA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
  
 
 0.562
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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