STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kthYPutative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa)    
Predicted Functional Partners:
comEB
Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans].
  
 
 0.941
kitH
Putative thymidine kinase; Best Blastp Hit: sp|P47848|KITH_STRGC THYMIDINE KINASE >gi|703442|gb|AAB02289.1| (L40415) thymidine kinase [Streptococcus gordonii].
  
 
 0.940
SMU_325
Putative dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
  
 
 0.940
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.938
SMU_668c
Ribonucleotide reductase, large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 
 0.934
holB
Best Blastp Hit: sp|P37540|HOLB_BACSU DNA POLYMERASE III, DELTA' SUBUNIT >gi|2126931|pir||S66061 DNA polymerase III delta' chain holB - Bacillus subtilis >gi|467421|dbj|BAA05267.1| (D26185) similar to B. subtilis DnaH [Bacillus subtilis] >gi|2632298|emb|CAB11807.1| (Z99104) DNA polymerase III (delta' subunit) [Bacillus subtilis].
  
 
 0.927
nrdG
Putative ribonucleotide reductase, small subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
  
 
 0.924
SMU_1660c
Conserved hypothetical protein; Involved in initiation control of chromosome replication. Belongs to the YabA family.
  
    0.838
SMU_1661c
Putative signal peptidase II; Best Blastp Hit: dbj|BAB03764.1| (AP001507) signal peptidase-like protein [Bacillus halodurans].
  
    0.796
rsmI
Conserved hypothetical protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
  
    0.791
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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