STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)    
Predicted Functional Partners:
urk
Putative uridine kinase; Best Blastp Hit: sp|O32033|URK_BACSU URIDINE KINASE (URIDINE MONOPHOSPHOKINASE) >gi|7449167|pir||G69728 uridine kinase udk - Bacillus subtilis >gi|2635179|emb|CAB14675.1| (Z99117) uridine kinase [Bacillus subtilis].
 
 0.998
pdp
Putative pyrimidine-nucleoside phosphorylase; Best Blastp Hit: pdb|1BRW|B Chain B, The Crystal Structure Of Pyrimidine Nucleoside Phosphorylase In A Closed Conformation >gi|6729724|pdb|1BRW|A Chain A, The Crystal Structure Of Pyrimidine Nucleoside Phosphorylase In A Closed Conformation.
  
 
 0.980
pyrF
Putative orotidine-5'-decarboxylase PyrF; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
 
 0.972
pyrH
Putative uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
   
 
 0.949
pyrR
Putative pyrimidine operon regulatory protein; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
   
 
 0.945
guaA
Putative GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.940
punA
Putative purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
  
 
 0.927
deoD
Best Blastp Hit: sp|O32810|DEOD_LACLC PURINE NUCLEOSIDE PHOSPHORYLASE (INOSINE PHOSPHORYLASE) (PNP) >gi|2281310|gb|AAC45498.1| (U80410) purine nucleoside phosphorylase [Lactococcus lactis subsp. cremoris].
  
 
  0.913
lacB
Best Blastp Hit: pir||D43258 galactose-6-phosphate isomerase subunit LacB - Streptococcus mutans.
 
  
 0.879
cmk
Putative cytidylate kinase; Best Blastp Hit: sp|P38493|KCY_BACSU CYTIDYLATE KINASE (CK) (CYTIDINE MONOPHOSPHATE KINASE) (CMP KINASE) >gi|7448348|pir||F69601 cytidylate kinase cmk - Bacillus subtilis >gi|533105|gb|AAA85149.1| (U11687) unknown [Bacillus subtilis] >gi|1146214|gb|AAC83961.1| (L47648) cytidine monophosphate kinase [Bacillus subtilis] >gi|2634707|emb|CAB14205.1| (Z99115) cytidylate kinase [Bacillus subtilis] >gi|2634724|emb|CAB14221.1| (Z99116) cytidylate kinase [Bacillus subtilis].
   
 
 0.818
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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