Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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SMU_320Putative 5-formyltetrahydrofolate cyclo-ligase; Best Blastp Hit: dbj|BAA28715.1| (AB001562) hypothetical protein [Streptococcus mutans]; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (178 aa)    
Predicted Functional Partners:
SMU_321
Conserved hypothetical protein; Best Blastp Hit: emb|CAB90755.1| (AJ400707) hypothetical protein [Streptococcus uberis].
  
  
 0.934
folD
Putative tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.926
purN
Putative phosphoribosylglycinamide formyltransferase (GART); Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
    
 0.907
SMU_318
Putative hippurate hydrolase; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.
  
    0.686
pbp2b
Penicillin-binding protein 2b; Best Blastp Hit: gb|AAC44614.1| (U58210) penicillin-binding protein 2b [Streptococcus thermophilus].
  
  
 0.548
SMU_874
Conserved hypothetical protein; Best Blastp Hit: dbj|BAB05348.1| (AP001512) unknown conserved protein [Bacillus halodurans].
     
 0.540
gltA
Best Blastp Hit: dbj|BAB05447.1| (AP001513) glutamate synthase (large subunit) [Bacillus halodurans].
  
    0.447
dapH
Putative tetrahydrodipicolinate succinylase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
       0.441
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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