STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMU_320Putative 5-formyltetrahydrofolate cyclo-ligase; Best Blastp Hit: dbj|BAA28715.1| (AB001562) hypothetical protein [Streptococcus mutans]; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (178 aa)    
Predicted Functional Partners:
folD
Putative tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.936
purN
Putative phosphoribosylglycinamide formyltransferase (GART); Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
    
 0.914
SMU_321
Conserved hypothetical protein; Best Blastp Hit: emb|CAB90755.1| (AJ400707) hypothetical protein [Streptococcus uberis].
  
    0.892
SMU_318
Putative hippurate hydrolase; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.
  
    0.527
pbp2b
Penicillin-binding protein 2b; Best Blastp Hit: gb|AAC44614.1| (U58210) penicillin-binding protein 2b [Streptococcus thermophilus].
  
  
 0.510
SMU_874
Conserved hypothetical protein; Best Blastp Hit: dbj|BAB05348.1| (AP001512) unknown conserved protein [Bacillus halodurans].
     
 0.428
glyA
Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.403
SMU_1505c
Hypothetical protein; Best Blastp Hit: emb|CAA37225.1| (X53057) phenylalanyl-tRNA synthetase beta subunit (AA 1-804) [Bacillus subtilis].
  
  
 0.401
syfB
Putative phenylalanyl-tRNA synthetase (beta subunit); Best Blastp Hit: sp|P17922|SYFB_BACSU PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN (PHENYLALANINE--TRNA LIGASE BETA CHAIN) (PHERS) >gi|7428487|pir||YFBSB phenylalanine--tRNA ligase (EC 6.1.1.20) beta chain - Bacillus subtilis >gi|1770031|emb|CAA99564.1| (Z75208) phenylalanyl-tRNA synthetase beta subunit [Bacillus subtilis] >gi|2635328|emb|CAB14823.1| (Z99118) phenylalanyl-tRNA synthetase (beta subunit) [Bacillus subtilis].
  
  
 0.401
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
Server load: medium (62%) [HD]
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